Transmucosal delivery devices with enhanced uptake

  • US 9,655,843 B2
  • Filed: 07/18/2016
  • Issued: 05/23/2017
  • Est. Priority Date: 07/21/2006
  • Status: Active Grant
First Claim
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1. A method for delivering buprenorphine to a human comprising:

  • administering a mucoadhesive biodegradable drug delivery device for transmucosal delivery, the device comprising;

    a bioerodible mucoadhesive layer comprising buprenorphine disposed in a polymeric diffusion environment, wherein the polymeric diffusion environment has a pH of between about 4 and about 7.5, anda polymeric barrier environment disposed adjacent to the mucoadhesive layer, and wherein a unidirectional diffusion gradient of buprenorphine is provided upon application to a buccal surface.

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