Nerve stimulator system

• US 9,656,074 B2
• Filed: 12/04/2015
• Issued: 05/23/2017
• Est. Priority Date: 11/04/2013
• Status: Active Grant

• Current Assignee: Electrocore, Llc
• Original Assignee: Electrocore, Llc
• Inventors: Simon, Bruce J., Errico, Joseph P., Mendez, Steven
• Primary Examiner(s): Wieland, Robert N
• Application Number:
  US14/959,183
• Publication Number:
  US 20160144180A1
• Time in Patent Office: 536 Days
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36153 Voltage A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37223 Circuits for electromagnetic coupling
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

Devices, systems and methods for treating at least one of a condition or a symptom of a patient by positioning a stimulation device at a target site adjacent to or near a nerve within a patient. The stimulation device comprising an antenna and one or more electrodes. Transmitting electrical energy to the antenna and generating electrical impulses within the stimulation device with the electrical energy and applying the series of electrical impulses to the nerve via the electrode. The electrical impulses sufficient to modulate the nerve and treat the condition or symptom of the patient; and which have on periods where the electrical impulses are generated and applied to the nerve and off periods between the electrical impulses, where the electrical energy is transmitted to the antenna.

Claims

1. A method for treating at least one of a condition or a symptom of a patient comprising:

positioning a stimulation device at a target site adjacent to a nerve within a patient or within a distance from the nerve such that one or more electrical impulses generated with the stimulation device can reach and modulate the nerve within the patient, the stimulation device comprising an antenna and one or more electrodes;

transmitting electrical energy to the antenna;

generating one or more electrical impulses within the stimulation device with the electrical energy;

applying the one or more electrical impulses to the nerve via the electrode, wherein the one or more electrical impulses are sufficient to modulate the nerve and treat the condition or symptom of the patient; and

wherein the one or more electrical impulses have on periods wherein each of the electrical impulses is generated and applied to the nerve and off periods between the electrical impulses, wherein the electrical energy is transmitted to the antenna during the off periods.

2. The method of claim 1, wherein the on periods have a duration of about 200 μ

S.

3. The method of claim 1, wherein the off periods have a duration of about 39,000 μ

S.

4. The method of claim 1, wherein the transmitting step is carried out via electrical radiative coupling.

5. The method of claim 1, wherein the electrical energy is transmitted from a controller located externally to the patient.

6. The method of claim 1, wherein the one or more electrical impulses each have a fixed amplitude.

7. The method of claim 6, further comprising varying a duration of the one or more electrical impulses via the stimulation device.

8. The method of claim 1, wherein each of the one or more electrical impulses comprises one or more pulses, wherein each of the one or more pulses comprises a fixed amplitude and a fixed duration, and wherein each of the one or more electrical impulses comprises a duration equal to a combined duration of the fixed duration of each of the one or more pulses.

9. The method of claim 8, further comprising varying the duration of each of the one or more electrical impulses by varying a number of the one or more pulses within such electrical impulse.

10. The method of claim 1, comprising:

storing the electrical energy within the stimulation device; and

releasing the electrical energy from a storage device to a pulse generator within the stimulation device to generate the one or more electrical impulses.

11. The method of claim 1, wherein the one or more electrical impulses have a fixed current.

12. The method of claim 1, wherein the one or more electrical impulses have a fixed voltage.

13. The method of claim 1, wherein the electrical energy is transmitted via a carrier signal comprising a frequency from about 800 MHz to about 1.2 GHz.

14. The method of claim 1, wherein the nerve is a vagus nerve.

15. A stimulation device for treating at least one of a condition or symptom of a patient comprising:

an enclosure configured for positioning adjacent to a nerve within a neck of a patient or within a distance from the nerve such that one or more electrical impulses generated with the stimulation device can reach and modulate the nerve within the neck of the patient;

an antenna coupled to the enclosure and configured to receive an input signal from a power source located remotely from the enclosure, wherein the input signal comprises electrical energy;

a storage device coupled to the antenna and housed within the enclosure, the storage device configured to store the electrical energy;

a pulse generator coupled to the storage device within the enclosure and configured to generate one or more electrical impulses based on the electrical energy, wherein the one or more electrical impulses have on periods wherein each of the one or more electrical impulses is generated and applied to the nerve and off periods between the on periods, wherein the pulse generator is configured to generate and apply the one or more electrical impulses such that the electrical energy is received by the antenna and stored within the storage device during the off periods of the one or more electrical impulses; and

one or more electrodes housed within the enclosure and coupled to the pulse generator, wherein the one or more electrodes are configured to conduct the one or more electrical impulses to the nerve sufficient to modulate the nerve.

16. The stimulation device of claim 15, wherein each of the one or more electrical impulses comprise one or more pulses having a fixed amplitude and a fixed duration, wherein the one or more electrical impulses each comprise a duration equal to a combined duration of the fixed duration of each of the one or more pulses.

17. The stimulation device of claim 15, wherein the on periods have a duration of about 200 μ

S.

18. The stimulation device of claim 15, wherein the off periods have a duration of about 39,000 μ

S.

19. The stimulation device of claim 16, wherein the pulse generator is configured to vary a number of the one or more pulses within the one or more electrical impulses to vary the duration of the one or more electrical impulses.

20. The stimulation device of claim 15, wherein the antenna is housed within the enclosure.

21. The stimulation device of claim 16, wherein the fixed duration of each of the one or more pulses is from about 100 μ

S to about 1000 μ

S.

22. The stimulation device of claim 15, wherein the input signal is received from the power source through electrical radiative coupling on a carrier signal comprising a frequency from about 300 MHz to about 6 GHz.

23. The stimulation device of claim 15, wherein the one or more electrical impulses comprise a frequency from about 1 Hz to about 50 Hz.