Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans

• US 9,656,096 B2
• Filed: 10/31/2011
• Issued: 05/23/2017
• Est. Priority Date: 12/05/2003
• Status: Active Grant

• Current Assignee: Endonovo Therapeutics, Inc.
• Original Assignee: Rio Grande Neurosciences, Inc.
• Inventors: Pilla, Arthur A.
• Primary Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US13/285,761
• Publication Number:
  US 20120089201A1
• Time in Patent Office: 2,031 Days
• Field of Search: 600 9- 15
• CPC Class Codes: A01G 7/04 Electric or magnetic or acoustic treatment of plants for promoting growth
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/008 for pain treatment or analgesia
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Apparatus and methods for delivering electromagnetic signals configured specifically to accelerate the asymmetrical kinetics of the binding of intracellular ions to their respective intracellular buffers, to enhance the biochemical signaling pathways plant animal and human molecules, cells, tissues, organs, portions of entire organisms and entire organisms employ for growth, repair and maintenance. Described herein are devices and methods that utilize repetitive bursts of waveforms configured to maximize the bound concentration of intracellular ions at their associated molecular buffers to enhance the biochemical signaling pathways living systems employ for growth, repair and maintenance. For example the systems and methods described herein may drive the binding of calcium to calmodulin (CaM), thereby enhancing the CaM-dependent nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway.

Claims

1. An electromagnetic treatment device for accelerating cytosolic ion binding to a corresponding cytosolic buffer to modulate a biochemical signaling pathway employed for tissue growth, repair and maintenance, the device configured to increase a voltage across a target ion binding pathway according to an asymmetrical binding kinetics of the target pathway, wherein the target ion binding pathway has an ion bound time, the device comprising:

a flexible and circular lightweight wire coil applicator; and

a signal generator configured to apply an electromagnetic signal to the applicator to induce, in the target pathway, a peak electric field between 1 to 100 V/m, wherein a signal generated by the signal generator has a pulse duration, random signal duration or carrier period which is less than twice the ion bound time, applied in a burst of waveforms having a pulse duration of between 1 μ

s and 100 μ

s, further wherein the signal generated has a burst duration between 1 to 10 msec of between 5 MHz to 50 MHz carrier waves, repeating between 1 and 10 bursts/sec.

2. The device of claim 1, wherein the applicator comprises an electrode applicator.

3. The device of claim 1, wherein the target ion binding pathway comprises calcium binding to calmodulin, and the ion bound time is between about 10⁻

2-10 sec.

4. The device of claim 1, wherein the electromagnetic treatment device is lightweight.

5. The device of claim 1, wherein the electromagnetic treatment device is disposable.

6. The device of claim 1, wherein the electromagnetic treatment device is portable.

7. The device of claim 1, wherein the lightweight electromagnetic treatment device is configured to be worn.

8. The device of claim 1, wherein the waveforms generated by the control circuit have a carrier frequency of 27.12 MHz.

9. The device of claim 1, further comprising an anatomical support configured to hold the treatment device adjacent to a target tissue.