Carboxylvinyl polymer-containing nanoparticle suspensions

  • US 9,662,398 B2
  • Filed: 11/12/2014
  • Issued: 05/30/2017
  • Est. Priority Date: 12/03/2009
  • Status: Active Grant
First Claim
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1. A topically administrable aqueous ophthalmic suspension composition comprising:

  • a carboxyvinyl polymer at a concentration of 0.1 to 0.5 w/v %, and wherein said carboxyvinyl polymer is a carbomer;

    a galactomannan at a concentration of 0.1 to 0.4 w/v %, said galactomannan selected from the group consisting of guar, native guar, and hydroxypropyl guar;

    borate at a concentration of 0.4 to 2.0 w/v %; and

    a sparingly soluble particulate compound, said compound having a solubility in water at 25°

    C. of 0.001 to 0.1 w/v % and wherein said sparingly soluble particulate compound is nepafenac at a concentration of 0.1 to 1.0 w/v %.

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