Polymer-nanostructure composition for selective molecular recognition

• US 9,664,677 B2
• Filed: 04/19/2011
• Issued: 05/30/2017
• Est. Priority Date: 04/19/2010
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Strano, Michael S., Barone, Paul Walter, Kim, Jong-Ho, Heller, Daniel A., Zhang, Jingqing
• Primary Examiner(s): Shibuya, Mark
• Assistant Examiner(s): MOERSCHELL, RICHARD P
• Application Number:
  US13/090,199
• Publication Number:
  US 20110257033A1
• Time in Patent Office: 2,233 Days
• Field of Search: None
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 33/542 with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.

Claims

1. A composition, comprising:

a complex, wherein the complex includes;

a nanostructure, wherein the nanostructure is a photoluminescent nanostructure,

wherein the photoluminescent nanostructure is a single-walled carbon nanotube; and

a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure,

wherein the polymer is a boronic acid functionalized phenoxy dextran; and

a selective binding site for the analyte on the complex.

2. The composition of claim 1, wherein the analyte is a monosaccharide, a polysaccharide, an amino acid, a nucleotide, an oligonucleotide, a lipid, a polylipid, a steroid, a peptide, a protein, riboflavin, or nitric oxide.

3. The composition of claim 1, wherein the analyte is 17-α

-estradiol, 2,4-dinitrophenol, acetylcholine chloride, α

-tocopherol, adenosine, adenosine-5′

-triphosphate, cyclic adenosine monophosphate, creatinine, cytidine, D-aspartic acid, D-fructose, D-galactose, D-glucose, D-mannose, dopamine, glycine, guanosine, histamine, L-ascorbic acid, L-citrulline, L-histidine, L-thyroxine, melatonin, NADH, quinine, salicylic acid, serotonin, sodium azide, sodium pyruvate, sucrose, thymidine, tryptophan, tyramin or urea.

4. The composition of claim 1, further comprising an amount of the analyte.

5. The composition of claim 4, wherein the analyte is a therapeutic.

6. A system comprising:

the composition of claim 1;

an electromagnetic radiation source having an excitation wavelength directed at the composition; and

a detector configured to receive an emission wavelength from the composition.