Systems and methods for determining respiration information from a photoplethysmograph

• US 9,675,274 B2
• Filed: 09/23/2011
• Issued: 06/13/2017
• Est. Priority Date: 09/23/2011
• Status: Active Grant

• Current Assignee: Nellcor Puritan Bennett Ireland
• Original Assignee: Nellcor Puritan Bennett Ireland
• Inventors: McGonigle, Scott, Ochs, James, Watson, James, Addison, Paul S.
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TRAN, THO Q
• Application Number:
  US13/243,853
• Publication Number:
  US 20130079606A1
• Time in Patent Office: 2,090 Days
• Field of Search: 600484, 600500, 600507, 600501, 600502, 600504
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A patient monitoring system may receive a photoplethysmograph (PPG) signal including samples of a pulse waveform. The PPG signal may demonstrate morphology changes based on respiration. The system may calculate morphology metrics from the PPG signal, the first derivative of the PPG signal, the second derivative of the PPG signal, or any combination thereof. The morphology metrics may demonstrate amplitude modulation, baseline modulation, and frequency modulation of the PPG signal that is related to respiration. Morphology metric signals generated from the morphology metrics may be used to determine respiration information such as respiration rate.

Claims

1. A method for determining respiration information, the method comprising:

receiving a photoplethysmograph (PPG) signal;

identifying, using a processor, a plurality of time domain fiducial points in the PPG signal;

generating, using the processor, a plurality of morphology metric signals from time domain portions of the PPG signal defined by the plurality of fiducial points, at least one of the plurality of morphology metric signals being selected from the group consisting of a down metric signal, a kurtosis signal of a derivative of the PPG signal, and a delta of second derivative of the PPG signal, wherein the down metric signal is based on a difference between an amplitude of a fiducial point defining a beginning of a time domain portion of the PPG signal and a minimum amplitude of the time domain portion of the PPG signal, and wherein the delta of second derivative of the PPG signal is based on a difference between a second derivative of a fiducial point of the PPG signal and a second derivative of another fiducial point of the PPG signal; and

processing, using the processor the plurality of morphology metric signals to determine a respiration rate from the plurality of morphology metric signals.

2. The method of claim 1 wherein generating the plurality of morphology metric signals comprises:

defining a plurality of fiducial-defined portions based on the fiducial points;

calculating a plurality of morphology metric values, at least one of which is selected from the group consisting of a down metric value, a kurtosis metric value, and a delta of second derivative metric value, wherein each morphology metric value is associated with a fiducial-defined portion; and

generating the plurality of morphology metric signals by processing the plurality of morphology metric values.

3. The method of claim 2 wherein generating the plurality of the morphology metric signals comprises interpolating the morphology metric values.

4. The method of claim 3 wherein generating the plurality of the morphology metric signals further comprises downsampling the interpolated morphology metric signals.

5. The method of claim 3 wherein generating the plurality of the morphology metric signals further comprises filtering the interpolated morphology metric signals.

6. The method of claim 2, further comprising attenuating a plurality of outlier morphology metric values.

7. A system comprising:

an interface configured to receive a photoplethysmograph (PPG) signal;

a processor configured to;

identify a plurality of time domain fiducial points in the PPG signal;

generate a plurality of morphology metric signals from time domain portions of the PPG signal defined by the plurality of fiducial points, at least one of the plurality of morphology metric signals being selected from the group consisting of a down metric signal, a kurtosis signal of a derivative of the PPG signal, and a delta of second derivative of the PPG signal, wherein the down metric signal is based on a difference between an amplitude of a fiducial point defining a beginning of a time domain portion of the PPG signal and a minimum amplitude of the time domain portion of the PPG signal, and wherein the delta of second derivative of the PPG signal is based on a difference between a second derivative of a fiducial point of the PPG signal and a second derivative of another fiducial point of the PPG signal; and

process the plurality of morphology metric signals to determine a respiration rate from the plurality of morphology metric signals.

8. The system of claim 7, the processor further configured to:

define a plurality of fiducial-defined portions based on the fiducial points;

calculate a plurality of morphology metric values, at least one of which is selected from the group consisting of a down metric value, a kurtosis metric value, and a delta of second derivative metric value, wherein each morphology metric value of the plurality of morphology values is associated with a fiducial-defined portion; and

generate the plurality of morphology metric signals by processing the plurality of morphology metric values.

9. The system of claim 8, wherein as part of generating the plurality of morphology metric signals, the processor further configured to interpolate the plurality of morphology metric values to generate interpolated morphology metric signals.

10. The system of claim 9, the processor further configured to downsample the interpolated morphology metric signals.

11. The system of claim 10, the processor further configured to filter the interpolated morphology metric signals.

12. The system of claim 8, wherein as part of generating the plurality of morphology metric signals, the processor further configured to attenuate a plurality of outlier morphology metric values.