Methods of colchicine administration

  • US 9,675,613 B2
  • Filed: 10/10/2014
  • Issued: 06/13/2017
  • Est. Priority Date: 08/20/2013
  • Status: Active Grant
First Claim
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1. A method of administering colchicine to a patient in need thereof while concomitantly administering a second drug that is an inhibitor of P-glycoprotein 1 (P-gp) but is not an inhibitor of the cytochrome P450 3A4 isozyme (CYP3A4), wherein the second drug is propafenone, wherein the method comprises:

  • (a) administering to the patient a fixed maintenance dose of colchicine in an amount of from about 0.6 to about 1.2 mg/day, for a maintenance period of a plurality of days, without administering propafenone;

    (b) after step (a), administering to the patient one or more therapeutically effective doses of the second drug; and

    (c) concomitantly with step (b), administering to the patient the fixed maintenance dose of colchicine of step (a) without dose reduction.

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