Method and apparatus for detecting atrial fibrillation

• US 9,681,819 B2
• Filed: 08/26/2014
• Issued: 06/20/2017
• Est. Priority Date: 08/30/2013
• Status: Active Grant

• Current Assignee: Joseph Wiesel
• Original Assignee: Joseph Wiesel
• Inventors: Wiesel, Joseph
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US14/469,023
• Publication Number:
  US 20150065891A1
• Time in Patent Office: 1,029 Days
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/361 Detecting fibrillation

Abstract

Method of determining atrial fibrillation including determining if a patient'"'"'s pulse beats form an irregular pattern and only if so, indicating the presence of an irregular pulse to the patient and obtaining an electrocardiogram for determining atrial fibrillation. Initially, a pulse is detected at regular time intervals of a first appendage of the patient when motionless using a pulse detector secured to the first appendage and pulse rhythms from a succession of time intervals are detected each corresponding to a respective interval of time between successive pulse beats of a sequence of the pulse beats. Then, an electrically conductive unit is attached to a second appendage of the patient, or a wearable electrocardiogram is attached to the patient, and electrocardiograms signals are detected simultaneously with pulse rhythms while the first appendage is motionless and analyzed to determine whether, in combination, they are indicative of atrial fibrillation. If so, an indication of atrial fibrillation is provided at least to the patient.

Claims

1. A method of determining atrial fibrillation, comprising:

performing a first stage of analysis to determining if pulse beats form an irregular pattern, the first stage comprising;

detecting a pulse of a first appendage of a patient by means of a pulse detector secured to the first appendage;

detecting pulse rhythms from a succession of time intervals each corresponding to a respective interval of time between successive pulse beats of a sequence of the pulse beats; and

determining, using a processor, whether the pulse beats form an irregular pattern; and

only when it is determined in the first stage that the pulse beats form an irregular pattern, indicating the presence of an irregular pulse and performing a second stage in which an electrocardiogram is obtained for determining atrial fibrillation, the second stage comprising;

detecting electrocardiogram signals simultaneously with pulse rhythms;

analyzing, using a processor, the detected pulse beats and electrocardiogram signal to determine whether, in combination, they are indicative of atrial fibrillation;

time shifting the electrocardiogram signal to generate a modified electrocardiogram signal, such that electrical activity which results in ventricular contraction occurs at a later time, said later time coinciding with pulse beats generated by the ventricular contraction; and

providing an indication of atrial fibrillation, when present.

2. The method of claim 1, further comprising, in the second stage,

securing an electrical conductor in contact with skin of a second appendage of the patient;

and

determining that the first appendage is motionless by means of a motion detector secured to the first appendage;

the electrocardiogram signals being detected simultaneously with pulse rhythms only after it is determined that the first appendage is motionless.

3. The method of claim 2, further comprising, in the second stage,

determining that the first appendage is not motionless by means of the motion detector secured to the first appendage;

and

providing an indication to the patient to place the first appendage in a motionless state when it is determined that the first appendage is not motionless.

4. The method of claim 2, further comprising, in the second stage,

determining whether the first appendage is motionless during the detection of the electrocardiogram signals simultaneously with pulse rhythm;

and

when it is determined that the first appendage is not motionless during the detection of the electrocardiogram signals simultaneously with pulse rhythm, providing an indication to the patient to place and maintain the first appendage in a motionless state for the duration of the detection of the electrocardiogram signals simultaneously with pulse rhythm.

5. The method of claim 2, wherein the motion detector comprises an accelerometer that measures acceleration of the first appendage.

6. The method of claim 1, wherein the step of detecting electrocardiogram signals comprises obtaining an electrocardiogram signal via an electrical lead from a wearable electrocardiogram configured to be attached to the limbs or the chest of the patient.

7. The method of claim 1, wherein the step of detecting electrocardiogram signals comprises:

attaching a wearable electrocardiogram attached to the limbs or the chest of the patient; and

transmitting, via radio waves, the electrocardiogram signal from the wearable electrocardiogram to a housing of the processor.

8. The method of claim 1, wherein the pulse detector comprises a light transmitter and light sensor, the method further comprising positioning the light transmitter to transmit light against skin of the patient and the light sensor to receive tight reflected from the skin of the patient.

9. The method of claim 1, further comprising periodically determining whether the first appendage used to detect the pulse is motionless by means of a motion detector secured to the first appendage and detecting pulse rhythms from a succession of time intervals only after it is determined that the first appendage is motionless and while the first appendance is motionless.

10. The method of claim 9, further comprising, in the first stage,

providing an indication to the patient to place the first appendage in a motionless state when it is determined that the first appendage is not motionless;

determining whether the first appendage is motionless during the succession of time intervals; and

when it is determined that the first appendage is not motionless during the succession of time intervals, providing an indication to the patient to place and maintain the first appendage in a motionless state for the duration of the succession of time intervals.

11. The method of claim 9, further comprising performing the step of detecting a pulse of a first appendage of a patient by means of a pulse detector secured to the first appendage automatically and periodically.

12. The method of claim 9, further comprising, in the second stage,

securing an electrical conductor in contact with skin of a second appendage of the patient;

and

determining that the first appendage is motionless;

the electrocardiogram signals being detected simultaneously with pulse rhythms only after it is determined that the first appendage is motionless.

13. The method of claim 1, further comprising performing the step of detecting a pulse of a first appendage of a patient by means of a pulse detector secured to the first appendage automatically and periodically.

14. The method of claim 1 wherein the pulse detector is integrated into a wristwatch.

15. The method of claim 1, wherein determining whether the pulse beats form an irregular pattern further comprises adjusting the determination to account for a previous irregular pattern that was found to be not atrial fibrillation by a previous second stage combined detection of pulse beats and electrocardiogram signal.

16. The method of claim 15, wherein adjusting the determination of an irregular pattern further comprises:

storing said previous irregular pattern as a historical non-atrial fibrillation pattern and comparing each new irregular pattern to said historical non-atrial fibrillation pattern and not performing the second stage if said pattern matches said historical non-atrial fibrillation pattern.

17. The method of claim 15, wherein adjusting the determination of an irregular pattern comprises increasing a threshold for pulse rates used in the determination of an irregular pattern.

18. The method of claim 15, wherein adjusting the determination of an irregular pattern further comprises:

increasing a threshold that is indicative of irregularity if exceeded by the quotient formed by dividing standard deviation of time intervals by mean of time intervals corresponding to a heartbeat.

19. The method of claim 17, wherein the threshold value is increased by beats per minute when it is not determined that the detected pulse beats and electrocardiogram signal in combination, are indicative of atrial fibrillation.

20. The method of claim 1, wherein the magnitude of the time shift is from about 200 to about to 700 msec.

21. The method of claim 1, wherein the step of analyzing the detected pulse beats and electrocardiogram signal to determine whether, in combination, they are indicative of atrial fibrillation further comprises deleting, on the modified ECG signal, R waves that occur without simultaneous pulse beat.

22. The method of claim 1, further comprising forming the modified ECG signal to include only the R waves that occur on the time shifted electrocardiogram and have a simultaneous pulse beat recording.

23. The method of claim 22, wherein the step of analyzing the detected pulse beats and electrocardiogram signal to determine whether, in combination, they are indicative of atrial fibrillation further comprises analyzing the modified ECG signal to determine whether it is regular and not atrial fibrillation or irregular and indicative of possible atrial fibrillation.

24. The method of claim 23, wherein the step of analyzing the detected pulse beats and electrocardiogram signal to determine whether, in combination, they are indicative of atrial fibrillation further comprises analyzing the modified ECG signal to determine presence of organized electrical activity due to atrial depolarization (“

p”

wave) occurring just prior to the selected R waves.

25. The method of claim 24, wherein the step of analyzing the detected pulse beats and electrocardiogram signal to determine whether, in combination, they are indicative of atrial fibrillation further comprises further comprising analyzing the modified ECG signal for the presence of “

p”

waves that determine the rhythm not to be indicative of atrial fibrillation and the absence of “

p”

waves determine the rhythm to be atrial fibrillation.