Vasopressin formulations for use in treatment of hypotension

  • US 9,687,526 B2
  • Filed: 10/10/2016
  • Issued: 06/27/2017
  • Est. Priority Date: 01/30/2015
  • Status: Active Grant
First Claim
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1. A method of increasing blood pressure in a human in need thereof, the method comprising:

  • a) providing a pharmaceutical composition for intravenous administration comprising;

    i) from about 0.01 mg/mL to about 0.07 mg/mL of vasopressin or a pharmaceutically-acceptable salt thereof;

    ii) acetic acid; and

    iii) water,wherein the pharmaceutical composition has a pH of 3.8;

    b) storing the pharmaceutical composition at 2-8°

    C. for at least 4 weeks; and

    c) intravenously administering the pharmaceutical composition to the human,wherein the administration provides to the human from about 0.01 units of vasopressin or the pharmaceutically-acceptable salt thereof per minute to about 0.1 units of vasopressin or the pharmaceutically-acceptable salt thereof per minute,wherein the human is hypotensive,wherein the pharmaceutical composition exhibits less than about 5% degradation after storage at 2-8°

    C. for about four weeks.

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