Arterial blood pressure monitoring devices, systems and methods for use while pacing

• US 9,687,656 B2
• Filed: 12/14/2009
• Issued: 06/27/2017
• Est. Priority Date: 07/08/2009
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Karst, Edward, Wenzel, Brian Jeffrey, Fayram, Timothy A., Keel, Allen J., Hou, Wenbo, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US12/637,574
• Publication Number:
  US 20110009755A1
• Time in Patent Office: 2,752 Days
• Field of Search: 600301, 600485, 600486, 600513, 607 17, 607 23
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: G03F 7/0002 Lithographic processes using patterning methods other than those involving the exposure to radiation, e.g. by stamping

Abstract

Provided herein are implantable systems, and methods for use therewith, for monitoring a patient'"'"'s arterial blood pressure while a patient'"'"'s heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient'"'"'s heart is obtained using a sensor or electrodes that are implanted remote from the patient'"'"'s heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

Claims

1. For use with an implantable system, a method for monitoring a patient'"'"'s arterial blood pressure, the method comprising:

(a) producing a ventricular pacing signal, which includes a plurality of ventricular pacing pulses, and pacing a patient'"'"'s heart using the ventricular pacing signal and at least one electrode implanted within or on the patient'"'"'s heart;

(b) using an implanted sensor or implanted electrodes, remote from the patient'"'"'s heart, to obtain a signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart while the patient'"'"'s heart is being paced;

(c) detecting one or more predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart obtained at step (b);

(d) determining one or more metrics indicative of pulse arrival time (PAT), by determining a time from a ventricular pacing pulse of the ventricular pacing signal to one or more of the predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart detected at step (c); and

(e) estimating the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT.

2. The method of claim 1, further comprising:

determining a value indicative of electromechanical delay (EMD) between delivery of pacing at step (a) and a mechanical cardiac contraction resulting from the pacing; and

wherein step (d) comprises determining at least one of the one or more metrics indicative of PAT also based on the value indicative of EMD.

3. The method of claim 2, wherein step (d) comprises determining at least one of the metrics indicative of PAT by determining a time from a ventricular pacing pulse of the ventricular pacing signal to a predetermined feature of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart, detected at step (c), minus the determined value indicative of EMD.

4. The method of claim 2, further comprising adjusting the pacing at step (a) to reduce variance of the value indicative of electromechanical delay (EMD).

5. The method of claim 1, wherein the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart obtained at step (b) comprises a photoplethysmography (PPG) signal or an impedance plethysmography (IPG) signal, and the one or more predetermined features of the PPG or IPG signal detected at step (d) is/are selected from the group consisting of:

minimum amplitude of the PPG or IPG signal;

maximum upward slope of the PPG or IPG signal;

maximum amplitude of the PPG or IPG signal;

dicrotic notch of the PPG signal or IPG;

maximum downward slope of the PPG or IPG signal prior to the dicrotic notch; and

maximum downward slope of the PPG or IPG signal following the dicrotic notch.

6. The method of claim 5, wherein step (d) includes:

filtering the PPG or IPG signal to reduce effects of respiratory noise, motion artifacts and baseline drift;

grouping a plurality of cycles of the PPG or IPG signal together and performing an outlier removal process to remove cycles of the PPG or IPG signal that are more than a specified threshold away from the mean of the plurality of cycles of the PPG or IPG signal;

averaging the cycles of PPG or IPG signal remaining after the performance of the outlier removal process to thereby determine an averaged PPG or IPG signal;

determining a first derivative and a second derivative of the averaged PPG or IPG signal; and

detecting, based on the first and second derivatives of the averaged PPG or IPG signal, the one or more predetermined features of the PPG or IPG signal.

7. The method of claim 1, wherein step (e) comprises estimating the patient'"'"'s arterial blood pressure by determining one or more value selected from the group consisting of:

a value indicative of systolic blood pressure (SBP) based on at least one of the one or more metrics indicative of PAT;

a value indicative of diastolic blood pressure (DBP) based on at least one of the one or more metrics indicative of PAT;

a value indicative of pulse pressure (PP) based on at least one of the one or more metrics indicative of PAT; and

a value indicative of mean arterial blood pressure (MAP) based on at least one of the one or more metrics indicative of PAT.

8. An implantable system, comprising:

a pulse generator configured to produce a ventricular pacing signal including a plurality of ventricular pacing pulses that are deliverable to a patient'"'"'s heart using at least one electrode implanted within or on the patient'"'"'s heart;

a plethysmography sensor configured to obtain a signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart while the patient'"'"'s heart is being paced with the voltage sufficient to cause capture;

an arterial blood pressure monitor configured to

detect one or more predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

determine one or more metrics indicative of pulse arrival time (PAT) based on times of a ventricular pacing pulse of the ventricular pacing signal and at least one of the one or more detected predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart; and

estimate the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT.

9. The implantable system of claim 8, wherein the implantable plethysmography sensor is selected from the group consisting of:

a photoplethysmography sensor, remote from the patient'"'"'s heart, configured to obtain a photoplethysmography (PPG) signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart; and

circuitry configured to obtain, using electrodes implanted remote from the patient'"'"'s heart, an impedance plethysmography signal (IPG) indicative of changes in arterial blood volume remote from the patient'"'"'s heart.

10. The implantable system of claim 8, wherein the arterial blood pressure monitor is configured to estimate the patient'"'"'s arterial blood pressure by determining one or more value selected from the group consisting of:

a value indicative of systolic blood pressure (SBP) based on at least one of the one or more metrics indicative of PAT;

a value indicative of diastolic blood pressure (DBP) based on at least one of the one or more metrics indicative of PAT;

a value indicative of pulse pressure (PP) based on at least one of the one or more metrics indicative of PAT; and

a value indicative of mean arterial blood pressure (MAP) based on at least one of the one or more metrics indicative of PAT.

11. The implantable system of claim 8, wherein the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart comprises a photoplethysmography (PPG) signal or an impedance plethysmography (IPG) signal, and wherein the arterial blood pressure monitor is configured to detect one or more predetermined features of the PPG or IPG signal selected from the group consisting of:

minimum amplitude of the PPG or IPG signal;

maximum upward slope of the PPG or IPG signal;

maximum amplitude of the PPG or IPG signal;

dicrotic notch of the PPG signal or IPG;

maximum downward slope of the PPG or IPG signal prior to the dicrotic notch; and

maximum downward slope of the PPG or IPG signal following the dicrotic notch.

12. The implantable system of claim 8, further comprising:

an electromechanical delay (EMD) monitor configured to determine a value indicative of EMD between delivery of pacing and a mechanical cardiac contraction resulting from the pacing.

13. The implantable system of claim 12, wherein the arterial blood pressure monitor is also configured to determine at least one of the one or more metrics indicative of PAT also based on the value indicative of EMD.

15. The implantable system of claim 12, further comprising a controller configured to adjust the pacing to reduce variance of the value indicative of electromechanical delay (EMD).

14. The implantable system of 13, wherein the arterial blood pressure monitor is configured to determine at least one of the metrics indicative of PAT by determining a time from a ventricular pacing pulse of the ventricular pacing signal to a detected predetermined feature of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart, minus the determined value indicative of EMD.

16. For use with an implantable system, a method for monitoring a patient'"'"'s arterial blood pressure, the method comprising:

(a) pacing a patient'"'"'s heart using a ventricular pacing pulse of a ventricular pacing signal;

(b) obtaining a photoplethysmography (PPG) signal or an impedance plethysmography (IPG) signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart while the patient'"'"'s heart is being paced;

(c) detecting one or more predetermined features of the PPG or IPG signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart obtained at step (b);

(d) determining one or more metrics indicative of pulse arrival time (PAT), by determining a time from a ventricular pacing pulse of the ventricular pacing signal to one or more of the predetermined features of the PPG or IPG signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart detected at step (c); and

(e) estimating the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT.