Systems and methods for wireless transmission of biopotentials

• US 9,693,708 B2
• Filed: 05/02/2008
• Issued: 07/04/2017
• Est. Priority Date: 05/04/2007
• Status: Active Grant

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: Towe, Bruce C.
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): Agahi, Puya
• Application Number:
  US12/598,871
• Publication Number:
  US 20100198039A1
• Time in Patent Office: 3,350 Days
• Field of Search: 600300, 600302, 600437, 600481, 600483, 600484
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: H01L 27/0808 Varactor diodes
• CPC Class Codes: H01L 29/93 Variable capacitance diodes, e.g. varactors

Abstract

The invention relates to wireless biotelemetry of low level bioelectric and biosensor signals by directly modulating the backscatter of a resonant circuit. Low level electrical analog or digital signals are directly applied to a resonant circuit containing a voltage-variable capacitor such as a varactor diode, that proportionally shifts the resonant frequency and so amplitude of radiofrequency backscatter in a way that represents analog bioelectric or biosensor waveform data. By strongly driving the resonant circuit with a radiofrequency source, a voltage variable capacitance can be caused to amplify the bio-signal level by a parametric process and so provide sufficient sensitivity to telemeter for low millivolt and microvolt level signals without additional amplification. A feature of the device is its simplicity and that it accomplishes both modulation and preamplification of low level sensor signals by the same variable capacitance circuit which reduces the device size and power consumption.

Claims

1. An apparatus comprising:

a completely passive electronic circuit having a varactor diode coupled to two electrodes configured to provide an inductance and a variable capacitance, wherein;

the electronic circuit is configured to receive an excitation signal and a biosignal, wherein the excitation signal has a frequency between 30 MHz and 10 GHz;

the electronic circuit has backscatter properties that vary in response to the biosignal, wherein the biosignal is generated by a biopotential that is detected by the two electrodes;

the electronic circuit is configured to transmit a backscatter signal when the electronic circuit receives the excitation signal and the biosignal; and

a characteristic of the biosignal can be determined by demodulating the backscatter signal.

2. The apparatus of claim 1, wherein the biosignal is generated by a sensor selected from the group consisting of:

a chemical, biochemical, magnetic, electromagnetic, physiological, and mechanical sensor.

3. The apparatus of claim 1, wherein the electronic circuit is configured to transmit the backscatter signal wirelessly.

4. The apparatus of claim 1, wherein the characteristic of the biosignal is an amplitude of the biosignal.

5. The apparatus of claim 1, wherein the characteristic of the biosignal is a frequency of the biosignal.

6. The apparatus of claim 1, wherein the excitation signal is a radio frequency signal.

7. The apparatus of claim 1, wherein the excitation signal is a digital logic signal.

8. The apparatus of claim 1, wherein the electronic circuit further comprises an isolating resistor.

9. The apparatus of claim 1, wherein the electronic circuit is configured to receive the biosignal in vivo.

10. The apparatus of claim 9, wherein the electronic circuit is configured to be implanted in a test subject.

11. The apparatus of claim 10, wherein the electronic circuit is configured to be inserted with a needle into the test subject.

12. The apparatus of claim 10, wherein the electronic circuit is configured to pass through the lumen of a 1 millimeter syringe needle.

13. The apparatus of claim 9, wherein the electronic circuit is configured to be placed on a skin surface of a test subject.

14. The apparatus of claim 1, wherein the electronic circuit comprises a pair of varactor diodes coupled back-to-back to form an equivalent series capacitance.

15. The apparatus of claim 1, further comprising a remote exciter configured to emit the excitation signal at a frequency equivalent to a resonant frequency of the electronic circuit.

16. The apparatus of claim 1, wherein the excitation signal has a frequency between 100 MHz and 3 GHz.

17. The apparatus of claim 1, wherein the excitation signal induces a voltage between 0.5 and 5.0 volts in the electronic circuit.

18. A method of measuring a biocharacteristic, the method comprising:

providing a passive electronic circuit according to claim 1, wherein the electronic circuit is configured to measure a biopotential;

providing an excitation signal to the electronic circuit, wherein the excitation signal has a frequency between 30 MHz and 10 GHz;

generating a biosignal with the biopotential and transmitting the biosignal to the electronic circuit;

transmitting a backscatter signal from the electronic circuit; and

measuring the backscatter signal to determine a characteristic of the biosignal.

19. The method of claim 18, wherein the electronic circuit comprises a resonant frequency that is variable.

20. The method of claim 18, wherein the electronic circuit has a base resonant frequency when a biosignal is not transmitted to the electronic circuit, and wherein the excitation signal is provided at the base resonant frequency.

21. The method of claim 18, wherein the biosignal is generated by a sensor selected from the group consisting of:

a chemical, biochemical, magnetic, electromagnetic, physiological, and mechanical sensor.

22. The method of claim 18, wherein the electronic circuit receives the biosignal in vivo.

23. The method of claim 22, further comprising implanting the electronic circuit subcutaneously in a test subject.

24. The method of claim 23, further comprising implanting the electronic circuit in a test subject with a needle.