Gel assembly

• US 9,694,169 B2
• Filed: 10/26/2012
• Issued: 07/04/2017
• Est. Priority Date: 10/26/2011
• Status: Active Grant

• Current Assignee: The Governors of the University of Alberta (University of Alberta)
• Original Assignee: The Governors of the University of Alberta (University of Alberta)
• Inventors: Serpe, Michael J.
• Primary Examiner(s): Buie-Hatcher, Nicole M
• Application Number:
  US13/662,117
• Publication Number:
  US 20130110040A1
• Time in Patent Office: 1,712 Days
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: B32B 15/08 of synthetic resin
• CPC Class Codes: Y10T 428/24942 including components having same physical characteristic in differing degree
• CPC Class Codes: Y10T 428/24975 No layer or component greater than 5 mils thick
• CPC Class Codes: Y10T 428/254 Polymeric or resinous material
• CPC Class Codes: Y10T 428/31678 Of metal
• CPC Class Codes: Y10T 428/31692 Next to addition polymer from unsaturated monomers

Abstract

A gel assembly comprising a polymeric gel layer between metal layers. A gel assembly process comprising providing a colloidal polymer in solution, drying the solution to form a polymeric gel layer and forming metal layers on either side of the polymeric gel layer. A method of drug delivery comprising loading a polymeric gel layer with drug, forming metal layers on either side of the polymeric gel layer, wherein the polymeric gel layer comprises a material that is sensitive to a stimulus, and subjecting the polymeric gel layer to the stimulus to release the drug from between or through the metal layers.

Claims

1. A gel assembly comprising a polymeric gel layer between metal layers in which the polymeric gel layer is formed as a colloidal gel comprising packed particles, the particles having an unstressed diameter and as packed particles having a center to center particle distance that is smaller than the unstressed diameter.

2. A gel assembly comprising a polymeric gel layer between metal layers in which the polymeric gel layer is loaded with drug.

3. A gel assembly comprising a polymeric gel layer between metal layers incorporated into a microbalance.