Dual chamber timing for leadless pacemakers using infrequent atrial signals and ventricular contractions

• US 9,694,186 B2
• Filed: 10/09/2014
• Issued: 07/04/2017
• Est. Priority Date: 09/08/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Carney, James K., Greenhut, Saul E.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Morales, Jon Eric C
• Application Number:
  US14/510,558
• Publication Number:
  US 20160067490A1
• Time in Patent Office: 999 Days
• Field of Search: 607 25, 607 17- 18
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/37276 characterised by means for reducing power consumption during telemetry
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

A method for adjusting a pacing rate in a dual-chamber, leadless pacemaker implanted in a heart may involve determining, with a leadless atrial pacemaker implanted in an atrium of the heart, that an intrinsic atrial contraction rate of the atrium is faster than a ventricular contraction rate, transmitting a first signal from the atrial pacemaker to a leadless ventricular pacemaker implanted in a ventricle of the heart to increase a ventricular pacing rate of the ventricular pacemaker, receiving the transmitted first signal with the ventricular pacemaker, and increasing the ventricular pacing rate, based on the received first signal.

Claims

1. A method for adjusting a pacing rate in a dual-chamber, leadless pacemaker system implanted in a heart, the method comprising:

sensing, with a sensor in a leadless atrial pacemaker implanted in an atrium of the heart, a first far-field R-wave indicating a depolarization of a ventricle of the heart;

determining, with a processor in the leadless atrial pacemaker and based on the sensed first far-field R-wave that an intrinsic atrial contraction rate of the atrium is faster than a ventricular contraction rate;

transmitting a first signal from the atrial pacemaker to a leadless ventricular pacemaker implanted in a ventricle of the heart to increase a ventricular pacing rate of the ventricular pacemaker;

receiving the transmitted first signal with the ventricular pacemaker;

increasing the ventricular pacing rate, based on the received first signal;

determining, with the ventricular pacemaker, that no signal has been received from the atrial pacemaker for a predetermined amount of time; and

decreasing the ventricular pacing rate.

2. The method of claim 1, further comprising, after the transmitting step:

sensing a second far-field R-wave with the sensor;

determining, with the processor and based on the sensed second far-field R-wave that the intrinsic atrial contraction rate is still faster than the ventricular contraction rate;

transmitting a second signal from the atrial pacemaker to the ventricular pacemaker to increase the ventricular pacing rate;

receiving the transmitted second signal with the ventricular pacemaker; and

increasing the ventricular pacing rate, based on the received second signal.

3. The method of claim 2, further comprising repeating the sensing, determining, transmitting, receiving and increasing steps, until the ventricular contraction rate exceeds the intrinsic atrial contraction rate.

4. The method of claim 3, further comprising:

determining, with the atrial pacemaker, that the ventricular contraction rate exceeds the intrinsic atrial rate; and

sending pacing pulses from the atrial pacemaker to the atrium to cause the atrium to contract at an atrial pacing rate that approximates the ventricular contraction rate.

5. The method of claim 1, further comprising:

determining, with the ventricular pacemaker, that a threshold ventricular pacing rate has been reached; and

discontinuing any further increases in the ventricular pacing rate.

6. The method of claim 1, wherein decreasing the ventricular pacing rate comprises decreasing the ventricular pacing rate by a predetermined decrement of at least 2 pulses per minute (ppm) and not more than 10 ppm.

7. The method of claim 1, wherein increasing the ventricular pacing rate comprises increasing the ventricular pacing rate by a predetermined increment of at least 2 pulses per minute (ppm) and not more than 10 ppm.

8. The method of claim 1, wherein increasing the ventricular pacing rate comprises increasing the ventricular pacing rate from a current rate to a next higher predetermined level of pacing rates.

9. A non-transitory, computer-readable storage medium storing a set of instructions that cause a dual-chamber, leadless pacemaker system implanted in a heart to perform a method, the method comprising:

sensing, with a sensor in a leadless atrial pacemaker implanted in an atrium of the heart, a first far-field R-wave indicating a depolarization of a ventricle of the heart;

determining, with a processor in the leadless atrial pacemaker and based on the sensed first far-field R-wave that an intrinsic atrial contraction rate of the atrium is faster than a ventricular contraction rate;

transmitting a first signal from the atrial pacemaker to a leadless ventricular pacemaker implanted in a ventricle of the heart to increase a ventricular pacing rate of the ventricular pacemaker;

receiving the transmitted first signal with the ventricular pacemaker;

increasing the ventricular pacing rate, based on the received first signal;

determining, with the ventricular pacemaker, that no signal has been received from the atrial pacemaker for a predetermined amount of time; and

decreasing the ventricular pacing rate.

10. The storage medium of claim 9, wherein the method further comprises, after the transmitting step:

sensing a second far-field R-wave with the sensor;

determining, with the processor and based on the sensed second far-field R-wave that the intrinsic atrial contraction rate is still faster than the ventricular contraction rate;

transmitting a second signal from the atrial pacemaker to the ventricular pacemaker to increase the ventricular pacing rate;

receiving the transmitted second signal with the ventricular pacemaker; and

increasing the ventricular pacing rate, based on the received second signal.

11. The storage medium of claim 10, wherein the method further comprises repeating the sensing, determining, transmitting, receiving and increasing steps until the ventricular contraction rate exceeds the intrinsic atrial contraction rate.

12. The storage medium of claim 11, wherein the method further comprises:

determining, with the atrial pacemaker, that the ventricular contraction rate exceeds the intrinsic atrial rate; and

sending pacing pulses from the atrial pacemaker to the atrium to cause the atrium to contract at an atrial pacing rate that approximates the ventricular contraction rate.

13. The storage medium of claim 9, wherein increasing the ventricular pacing rate comprises increasing the ventricular pacing rate by a predetermined increment of at least 2 pulses per minute (ppm) and not more than 10 ppm.

14. The storage medium of claim 9, wherein increasing the ventricular pacing rate comprises increasing the ventricular pacing rate from a current rate to a next higher predetermined level of pacing rates.

15. An implantable, dual-chamber, leadless pacemaker system, comprising:

an atrial leadless pacemaker, comprising;

a sensing module configured to sense signals indicative of ventricular contractions;

a processing module configured to determine whether an intrinsic atrial contraction rate is greater than a ventricular contraction rate; and

a communication module configured to transmit a signal to a ventricular leadless pacemaker to increase a ventricular pacing rate in response to instructions from the processing module to increase the ventricular pacing rate; and

a ventricular leadless pacemaker, comprising;

a sensing module configured to receive the transmitted signal from the atrial pacemaker; and

a processing module configured to increase the ventricular pacing rate according to the received signal, to determine when no signal has been received from the atrial pacemaker for a predetermined amount of time, and to decrease the ventricular pacing rate when no signal has been received from the atrial pacemaker for the predetermined amount of time,

wherein the processing module of the atrial pacemaker is further configured to begin pacing the atrium at an atrial pacing rate that is faster than the intrinsic atrial contraction rate and that at least approximately matches the ventricular pacing rate.

16. The system of claim 15, wherein the sensing module of the atrial pacemaker is configured to sense at least one of far-field R-waves or heart sounds.

17. The system of claim 15, wherein the processing module of the atrial pacemaker is further configured to determine that the ventricular contraction rate exceeds the intrinsic atrial contraction rate and to discontinue transmission of signals from the atrial pacemaker to the ventricular pacemaker.

18. The system of claim 15, wherein the processing module of the ventricular pacemaker is configured to increase the ventricular pacing rate by a predetermined increment and decrease the ventricular pacing rate by a predetermined decrement that is less than the predetermined increment.

19. The system claim 15, wherein the processing module of the ventricular pacemaker is configured to increase and decrease the ventricular pacing rate between predetermined, quantized levels.

20. The system of claim 15, wherein the processing module of the ventricular pacemaker is further configured to determine that a threshold ventricular pacing rate has been reached and to discontinue increasing the ventricular pacing rate.