Method and device for detection of bioavailable drug concentration in a fluid sample

• US 9,700,246 B2
• Filed: 10/15/2009
• Issued: 07/11/2017
• Est. Priority Date: 10/15/2008
• Status: Active Grant

• Current Assignee: US Department of The Army (Government of the United States of America), University of Memphis Research Foundation
• Original Assignee: University of Memphis Research Foundation, University of Tennessee Research Foundation (University of Tennessee)
• Inventors: Guo, Jidong, Chaum, Edward, Lindner, Erno
• Primary Examiner(s): WESTON, TIFFANY C
• Application Number:
  US13/124,036
• Publication Number:
  US 20120116195A1
• Time in Patent Office: 2,826 Days
• Field of Search: 204412, 204416, 204418, 20440306, 204405, 2057825, 205782, 604 65, 604503
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Claims

1. An electrochemical, voltammetric sensor device comprising:

at least two or more electrodes and a water-immiscible coating that surrounds the electrodes,

wherein the water-immiscible coating is in contact with the electrodes, wherein the water-immiscible coating comprises about 15 to about 67 wt percent polyvinylchloride (PVC), about 33 to about 85 wt percent 2-nitrophenyl octal ether (o-NPOE), and about 0.001 to about 15 wt percent tetradecylammonium tetrakis(pentoflurorphenyl)borate (TDATPFPB),

wherein the water-immiscible coating partitions a hydrophobic drug from a fluid sample wherein the partitioned drug is oxidized within the water-immiscible coating, wherein the electrodes measure an oxidation/reduction current within the water-immiscible coating, and wherein the measured oxidation/reduction current indicates the concentration of a drug in the fluid sample.

2. The electrochemical, voltammetric sensor device of claim 1, wherein the electrodes comprise a working electrode, a reference electrode, a counter electrode, or any combination thereof.

3. The electrochemical, voltammetric sensor device of claim 2, wherein the working electrode comprises glassy carbon, the reference electrode is composed of silver, and the counter electrode comprises platinum.

6. A catheter comprising:

a body and a lumen, and an electrochemical, voltammetric sensor device according to claim 1 or 4 in communication with the lumen or externally of the body, wherein the water-immiscible coating is capable of partitioning a bioavailable drug directly from a body fluid.

7. A micro fluidic device comprising a micro fluid channel and an electrochemical, voltammetric sensor device according to claim 1, or 4 in communication with the microfluid channel.

4. An electrochemical, voltammetric sensor device comprising:

two or more electrodes and a water-immiscible coating that surrounds the electrodes, wherein the water-immiscible coating is in contact with the electrode and comprises about 15 to about 67 wt percent polyvinylchloride (PVC), about 33 to about 85 wt percent 2-nitrophenyl octyl ether (o-NPOE), and about 0.001 to about 15 wt percent tetradecylammonium tetrakis(pentoflurorphenyl)borate (TDATPFPB).

5. The electrochemical, voltammetric sensor device of claim 4, wherein the two or more electrodes comprise a glassy carbon working electrode, a silver reference electrode, a platinum counter electrode, or any combination thereof.