Antagonists of the glucagon receptor
First Claim
1. A method of treating a disease or condition responsive to decreased hepatic glucose production or responsive to lowered blood glucose levels, the method comprising the step of administering to an animal a therapeutically effective amount of a compound of general formula (I)
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Abstract
The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
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10 Claims
- 1. A method of treating a disease or condition responsive to decreased hepatic glucose production or responsive to lowered blood glucose levels, the method comprising the step of administering to an animal a therapeutically effective amount of a compound of general formula (I)
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3. A method for treating a disease or condition selected from the group consisting of:
- Type I diabetes, Type II diabetes, impaired glucose tolerance, insulin resistance, postprandial hyperglycemia, fasting hyperglycemia, accelerated gluconeogenesis, increased or excessive (greater than normal levels) hepatic glucose output, hyperinsulinemia, hyperlipidemia, dyslipidemia, hypercholesterolemia, atherosclerosis, obesity, Metabolic Syndrome X, the method comprising the step of administering to an animal a therapeutically effective amount of a compound of general formula (I)
- View Dependent Claims (4, 5, 6, 9, 10)
Specification