System for ventricular arrhythmia detection and characterization

• US 9,706,952 B2
• Filed: 09/19/2011
• Issued: 07/18/2017
• Est. Priority Date: 01/06/2011
• Status: Active Grant

• Current Assignee: PixArt Imaging Incorporated
• Original Assignee: Siemens Healthcare GMBH (Siemens AG)
• Inventors: Zhang, Hongxuan
• Primary Examiner(s): Henson, Mischita
• Assistant Examiner(s): LIAO, CHRISTINE Y
• Application Number:
  US13/235,612
• Publication Number:
  US 20120179382A1
• Time in Patent Office: 2,129 Days
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A system for heart performance characterization and abnormality detection detects peaks and at least one of, a valley and a baseline comprising a substantially zero voltage level, of received signal data representing oxygen content of blood in a patient vessel over multiple heart beat cycles. The signal processor determines signal parameters including at least one of, (a) a signal amplitude magnitude between a maximum peak and minimum valley, of the received signal data, (b) a signal amplitude magnitude between a maximum peak and a baseline, of the received signal data and (c) a signal amplitude magnitude between a second highest maximum peak and minimum valley, of the received signal data. The system compares a determined signal parameter or value derived from the determined signal parameter, with a threshold value and generates an alert message associated with the threshold, in response to the comparison.

Claims

1. A system for heart performance characterization and abnormality detection, comprising:

an interface for receiving signal data, acquired by one or more sensors, representing oxygen content of blood in a patient vessel over a plurality of heart beat cycles and electrocardiogram (ECG) signal data representing heart activity of the patient;

a signal processor for;

detecting one or more peaks, a valley and a baseline comprising a substantially zero voltage level of the received signal data representing oxygen content of blood, wherein a peak of the signal data representing oxygen content of blood is detected by;

determining a peak in the ECG signal data, wherein the ECG signal data includes a Q wave, an R wave, and a T wave, and wherein the peak is determined from a search among the Q wave, R wave and T wave;

determining windows of the signal data representing oxygen content of blood in which a peak in the signal data representing oxygen content of blood is expected, wherein the peak in the ECG signal data is the basis for the determination of the windows in which the peak in the signal data representing oxygen content of blood is expected;

searching within the windows to identify the peak in the signal data representing the oxygen content of blood;

synchronizing the peak of the signal data representing the oxygen content of blood with the peak in the ECG signal data;

utilizing the synchronized peak of the signal data representing the oxygen content of blood and the peak in the ECG signal data for detection and characterization of cardiac arrhythmia and pathology;

detecting, with a timing detector, a time duration between the synchronized peak of the ECG signal data and peak of the received oxygen content signal data of the patient;

determining signal parameters including at least one of

(a) a signal amplitude magnitude between a maximum peak and minimum valley, of the received oxygen content signal data,

(b) a signal amplitude magnitude between the maximum peak and the baseline, of the received oxygen content signal data and

(c) a signal amplitude magnitude between a second highest maximum peak and minimum valley, of the received oxygen content signal data; and

evaluating a health status of the patient based on the detected time duration between the synchronized peak of the ECG signal data and peak of the received oxygen content signal data of the patient; and

a comparator for comparing a determined signal parameter or a value derived from the determined signal parameter with a threshold value to provide a comparison indicator identifying a medical condition of the patient; and

a patient monitor for in response to said comparison indicator, generating an alert message associated with the threshold value indicating the medical condition of the patient.

2. The system according to claim 1, wherein

said oxygen content signal data is digitally sampled data and

said oxygen content signal data representing oxygen content of blood comprises SPO2 signal data indicating Saturation of Hemoglobin with Oxygen as measured by pulse Oximetry.

3. The system according to claim 1, wherein

said signal processor detects peaks of a waveform within the received oxygen content signal data using a peak detector and detects a valley as a negative peak in the oxygen content signal data using the peak detector and

said signal processor detects the baseline of the signal by filtering out a static (DC) voltage signal component from the received oxygen content signal data and by determining a substantially zero voltage level of the resultant filtered received oxygen content signal data.

4. The system according to claim 3, wherein

said signal processor detects valleys of a waveform within the received oxygen content signal data by using a valley in segmenting the received oxygen content signal data into windows where a valley is expected and identifying the valley within a window.

5. The system according to claim 4, wherein

said signal processor segments the received oxygen content signal data by synchronizing a detection window with respect to a detected valley.

6. The system according to claim 1, wherein

said signal processor determines signal parameters including at least one of,

(i) a signal amplitude magnitude between the second highest maximum peak and the baseline, of the received oxygen content signal data,

(ii) a signal amplitude magnitude between the minimum valley and the baseline, of the received oxygen content signal data and

(iii) a signal amplitude magnitude between the maximum peak and the second highest maximum peak, of the received oxygen content signal data.

7. The system according to claim 1, wherein

said received signal data comprises at least one of intra-cardiac electrograms (ICEG), dP/dt and hemodynamic signal data, wherein P is the pressure in a ventricle of the patient and t is time.

8. The system according to claim 1, wherein

said signal processor detects peaks in response to synchronization using at least one of an intra-cardiac electrograms (ICEG) dP/dt and hemodynamic signal, wherein P is the pressure in a ventricle of the patent and t is time.

9. The system according to claim 1, wherein

said timing detector detects time duration between a detected peak and a detected valley in the received oxygen content signal data.

10. The system according to claim 9, wherein

said timing detector detects time duration between

(i) the maximum peak to the minimum valley, of the received oxygen content signal data;

and

(ii) the minimum valley to the maximum peak, of the received oxygen content signal data.

11. The system according to claim 1, wherein

said timing detector detects time duration between a detected peak of a blood pressure representative signal of the patient and a detected peak of the received oxygen content signal data of the patient.

12. The system according to claim 1, wherein

said signal processor determines a ratio of the determined signal parameters.

13. The system according to claim 1, wherein

said threshold value is derived from received oxygen content signal data for said patient.

14. The system according to claim 1, wherein

said threshold value is derived from received oxygen content signal data for a population of patients.

15. The system according to claim 14, wherein

said population of patients has similar demographic characteristics including at least two of, (a) age, (b) weight, (c) gender and (d) height, to those of said patient.

16. The system according to claim 1, wherein

said signal processor dynamically adjusts said threshold value in response to a determined sensitivity of arrhythmia detection.

17. The system according to claim 1, wherein

said signal processor calculates a standard deviation of a determined parameter over a plurality of heart cycles;

and

said patient monitor, in response to a comparison indicator indicating a calculated standard deviation value exceeds a predetermined threshold value, generates an alert message.

18. The system according to claim 1, including

a repository of mapping information, associating ranges of a determined parameter with corresponding medical conditions;

and

said comparator compares the determined parameter with said ranges to provide a comparison indicator identifying the medical condition.

19. The system according to claim 18, wherein

said mapping information is predetermined, and wherein said predetermined mapping information associates ranges of determined parameters with particular patient demographic characteristics and with corresponding medical conditions and said system uses patient demographic data including at least one of, age weight, gender and height in comparing a determined parameter with said ranges and generating an alert message indicating a potential medical condition.

21. The system of claim 1, wherein the zero voltage level of the baseline is determined by the signal processor based on a filtered received oxygen content signal data, wherein the signal processor filters out a static voltage signal component from the received oxygen content signal data.

20. A method for heart performance characterization and abnormality detection, comprising the activities of:

receiving signal data, acquired by one or more sensors, representing oxygen content of blood in a patient vessel over a plurality of heart beat cycles and electrocardiogram (ECG) signal data representing heart activity of the patient;

detecting one or more peaks, a valley, and a baseline comprising a substantially zero voltage level, of the received signal data, wherein a peak of the signal data representing oxygen content of blood is detected by;

determining a peak in the ECG signal data, wherein the ECG signal data includes a Q wave, an R wave, and a T, and wherein the peak is determined from a search among the Q wave, R wave and T wave;

determining windows of the signal data representing oxygen content of blood in which a peak in the signal data representing oxygen content of blood is expected, wherein the peak in the ECG signal data is the basis for the determination of the windows in which the peak in the signal data representing oxygen content of blood is expected;

searching within the windows to identify the peak in the signal data representing the oxygen content of blood;

synchronizing the peak of the signal data representing the oxygen content of blood with the peak in the ECG signal data;

utilizing the synchronized peak of the signal data representing the oxygen content of blood and the peak in the EG signal data for detection and characterization of cardiac arrhythmia and pathology;

detecting, with a timing detector, a time duration between the synchronized peak of the ECG signal data and peak of the received oxygen content signal data of the patient;

determining signal parameters including at least one of,

(a) a signal amplitude magnitude between a maximum peak and minimum valley, of the received signal data,

(b) a signal amplitude magnitude between a maximum peak and a baseline, of the received signal data and

(c) a signal amplitude magnitude between a second highest maximum peak and minimum valley, of the received signal data

evaluating a health status of the patient based on the detected time duration between the synchronized peak of the ECG signal data and peak of the received oxygen content signal data of the patient; and

in response to comparing a determined signal parameter or a value derived from the determined signal parameter with a threshold value, identifying a medical condition of the patient, and generating an alert message associated with the threshold value indicating the medical condition of the patient.