Sorbent cartridge to measure solute concentrations

• US 9,707,328 B2
• Filed: 03/08/2013
• Issued: 07/18/2017
• Est. Priority Date: 01/09/2013
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Pudil, Bryant J., Meyer, Thomas E., Lura, David B., Gerber, Martin T.
• Primary Examiner(s): Menon, Krishnan S
• Assistant Examiner(s): Spies, Bradley R
• Application Number:
  US13/791,755
• Publication Number:
  US 20140190876A1
• Time in Patent Office: 1,593 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/288 Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 1/3406 Physical characteristics of the filtrate, e.g. urea
• CPC Class Codes: A61M 1/3413 Diafiltration
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: B01D 15/08 Selective adsorption, e.g. chromatography
• CPC Class Codes: B01D 15/361 Ion-exchange
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/048 containing phosphorus, e.g. phosphates, apatites, hydroxyapatites
• CPC Class Codes: B01J 20/06 comprising oxides or hydroxides of metals not provided for in group B01J20/04
• CPC Class Codes: B01J 20/08 comprising aluminium oxide or hydroxide; comprising bauxite
• CPC Class Codes: B01J 20/20 comprising free carbon; comprising carbon obtained by carbonising processes
• CPC Class Codes: B01J 20/28052 : Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 2220/49 : Materials comprising an indicator, e.g. colour indicator, pH-indicator
• CPC Class Codes: B01J 39/10 : Oxides or hydroxides
• CPC Class Codes: B01J 39/12 : Compounds containing phosphorus
• CPC Class Codes: B01J 39/18 : Macromolecular compounds B01J39/17 takes precedence
• CPC Class Codes: B01J 41/10 : Inorganic material
• CPC Class Codes: B01J 41/12 : Macromolecular compounds
• CPC Class Codes: B01J 47/012 : using portable ion-exchange apparatus
• CPC Class Codes: B01J 47/026 : using columns or beds of different ion exchange materials in series
• CPC Class Codes: B01J 47/14 : Controlling or regulating

Abstract

A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.

Claims

1. A sorbent based monitoring system for measuring a solute concentration of at least one component of a fluid, comprising:

a sorbent regeneration system for regeneration of the fluid, wherein the sorbent regeneration system has a plurality of material layers formed in one or more regeneration module, wherein the fluid is conveyed to the one or more regeneration module;

wherein a part of a primary flow stream contacts at least two sensors;

wherein a first sensor, upstream from at least one material layer in the one or more regeneration module, contacts fluid that has not contacted a specified material layer, and a second sensor, downstream from the specified material layer, contacts fluid that has contacted the specified material layer; and

a processor determining a solute concentration in the fluid based on a difference between a measurement from the first sensor and the second sensor.

2. The system of claim 1, wherein the fluid is a dialysate for hemodialysis or hemodiafiltration and the one or more regeneration module receives a spent dialysate containing at least one species from the dialysate outlet port of a dialyzer and removes at least a portion of a species from the dialysate to regenerate the dialysate for recirculation of at least a portion of the regenerated dialysate to the dialysate inlet port of a dialyzer.

3. The system of claim 1, wherein the fluid is a filtrate and the one or more regeneration module receives a filtrate containing at least one species from the filtrate outlet port of a hemofilter and removes at least a portion of a species from the filtrate to regenerate a replacement fluid for return of at least a portion of the regenerated replacement fluid to a conduit of an extracorporeal circuit.

4. The system of claim 1, wherein the fluid is a dialysate for peritoneal dialysis and the one or more regeneration module receives a spent dialysate containing at least one species from a subject receiving treatment and removes at least a portion of a species from the dialysate to regenerate the dialysate for recirculation of at least a portion of the regenerated dialysate to the subject receiving treatment.

5. The system of any one of claims 1, 2, 3 or 4, wherein at least one sensor measures conductivity of the fluid.

6. The system of any one of claims 1, 2, 3 or 4, wherein at least one sensor measures at least one characteristic of the fluid selected from the group of pH and ammonium ion.

7. A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid, comprising:

the sorbent system of claim 1 having the first sensor contacting at least a first position of the at least one material layer or a first position from the primary flow stream; and

the second sensor contacting either a second position of the at least one material layer or a second position from the primary flow stream;

wherein the first sensor and the second sensor determine the amount or concentration of at least one solute.

8. The system of claims 1 or 7, wherein the monitoring system comprises at least two sensors.

9. The system of claims 1 or 7, wherein the monitoring system comprises a plurality of sensors.

10. The system of claim 8, wherein at least one of said sensors forms part of a conductivity meter.

11. The system of claim 9, wherein at least one of said sensors forms part of a conductivity meter.

12. The system of claims 1 or 7, wherein a plurality of sensors are configured to measure one or more solute concentrations.

13. The system of claim 10, wherein said meter is configured to measure the conductivity of at least one solute concentration.

14. The system of claim 11, wherein said meter is configured to measure the conductivity of at least one solute concentration.

15. The system of claims 1 or 7, wherein the monitoring system comprises a plurality of sensors that can measure the conductivity of a plurality of separate material layers and flow streams.

16. The system of claim 1, further comprising at least two sensing points within any one of the material layers.

17. The system of claim 1, further comprising at least two sensing points within different material layers.

18. The system of claim 1, wherein the plurality of material layers include one or more selected from a urease-containing material, alumina, zirconium phosphate, magnesium phosphate, zirconium oxide, and activated carbon.

19. The system of claim 18, wherein the solute concentration of urea is measured.

20. The system of claim 19, wherein the solute concentration of urea in the fluid entering a material layer is determined by obtaining a first measurement from the fluid before contacting a urease containing layer and a second measurement from the fluid after having contacted the urease containing layer.

21. The system of claim 20, wherein the first and second measurements are conductivity measurements.

22. The system of claim 20, wherein the first and second measurements are pH measurements.

23. The system of claim 18, wherein at least one sensor is an ammonium sensor and the solute concentration of urea in the fluid is determined in part by measurement of an ammonium ion concentration in the fluid after contacting a urease containing layer.

24. The system of claim 18, wherein a solute concentration of urea from an amount of carbon dioxide release from said urease-containing material is measured.

25. The system of claim 1, further comprising a fluid flow path in fluid communication with the sorbent regeneration system.

26. The systems of claim 25, further comprising a fluid flow monitor attached to said fluid flow path for determining an amount of fluid flowing through the sorbent regeneration system.

27. The system of claim 26, wherein said fluid flow monitor is configured to calculate a mass flow rate of urea contained in the fluid stream.

28. The system of claim 27, wherein said fluid flow monitor is configured to calculate a total amount of urea removed in a time interval.

29. The system of claim 28, wherein the system is configured to determine what portion of the regenerative capacity of the one or more regeneration module has been consumed based on the total amount of urea removed.

30. The system of claim 29, wherein an estimate of a conductivity meter of a subject undergoing treatment is used to estimate the Urea Reduction Ratio for the treatment.

31. The system of claim 29 wherein the system is configured to determine an amount of bicarbonate released from the sorbent regeneration system based on the total amount of urea removed.

32. The system of claim 29, wherein the system is configured to determine a further amount, if any, to be infused by reconstitution system, based on a determination of an amount of bicarbonate released from a sorbent system.

33. The system of claim 1, further comprising a multiplexer receiving signals from at least one sensor.

34. The system of claim 33, further comprising at least one processor for processing the signals received from the multiplexer.

35. The system of claim 1, wherein the fluid such as spent dialysate exiting a dialyzer is conveyed through the one or more regeneration module and does not contact at least one other material layer;

and at least one sensor in contact with the fluid that has contacted the at least one other material layer within the sorbent system.

36. The system of claims 1 or 7, wherein said monitoring system is configured to monitor the progress of a treatment session.

37. The system of claims 1 or 7, wherein said monitoring system is configured to detect system performance problems.

38. The system of claim 1, wherein the one or more material layers include a divalent ion capturing resin selective for divalent cations.

39. The system of claim 38, wherein the divalent ion capturing resin includes an ion exchange resin.

40. The system of claim 39, wherein the divalent ion capturing resin includes a chelating resin.

41. The system of claim 38, wherein a first conductivity measurement is taken for fluid that has not contacted the divalent ion capturing resin and a second conductivity measurement is taken after the fluid has contacted the divalent ion capturing resin and wherein the total combined magnesium and calcium ion concentration of a fluid is determined from the first conductivity reading and the second conductivity reading.

42. The system of claim 39, wherein the divalent ion capturing resin gives off hydrogen ions in exchange for calcium and magnesium ions.

43. The system of claim 42 wherein the hydrogen ions released by the divalent ion capturing layer causes an increase in ammonium ions and a decrease of ammonia molecules in a fluid containing urea that has contacted a urease containing layer.

44. The system of claim 1, further comprising a dialysate flow path in fluid communication with the one or more regeneration module wherein the dialysate flow path is a controlled compliant flow path.

45. The system of claim 1, further comprising a dialysate flow path in fluid communication with the one or more regeneration module wherein the dialysate flow path has a small volume and a control valve for selectively metering fluid in and out of a first recirculation flow path.

46. The system of claim 45, wherein the system selectively meters fluid into and out of the first recirculation flow path using any one of a control pump, a water pump, an acid concentrate pump, a replacement fluid pump, and combinations thereof.

47. The system of claim 1, further comprising a dialysate flow path in fluid communication with the one or more regeneration module wherein the dialysate flow path is capable of moving fluid bi-directionally in a first recirculation flow path.

48. The system of claim 1, wherein the at least one material layers of the one or more regeneration module includes a first material layer including an ion exchange resin, a second material layer including a urease material, and a third material layer including a sorbent material, the second material layer being positioned between the first material layer and the third material layer.

49. The system of claim 48, wherein the fluid contacts the first material layer prior to contacting the third material layer.

50. The system of claim 1, wherein the at least one material layer of the one or more regeneration module includes a first material layer including a urease, a second material layer including zirconium phosphate and zirconium oxide, and a third material layer including a sorbent material, the second material layer being positioned between the first material layer and the third material layer.

51. The system of claim 50, wherein the second material layer includes a first sub-layer including zirconium phosphate and a second sub-layer including zirconium oxide, the second sub-layer being positioned between the first sub-layer and the third material layer.

52. The system of claim 51, wherein the third material layer includes activated carbon.

53. The system of claim 1, wherein at least one sensor is positioned within the primary flow stream and contacts the primary flow stream before the primary flow stream exits a last material contained within the one or more regeneration module.

54. The system of claim 1, wherein each of the first sensor and second sensor are positioned in any one of:

a primary flow path outside of the one or more regeneration module, in a primary flow path within the one or more regeneration module, embedded within a material layer, in a diverted sample stream, and combinations thereof.