Multiple dosage injector with rack and pinion dosage system

• US 9,707,354 B2
• Filed: 03/11/2014
• Issued: 07/18/2017
• Est. Priority Date: 03/11/2013
• Status: Active Grant

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: Madsen, Patrick, Pflaumer, Hans, Swanson, Kevin
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US14/204,641
• Publication Number:
  US 20140257197A1
• Time in Patent Office: 1,225 Days
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31586 performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.

Claims

1. A dispensing mechanism, comprising:

a housing having a proximal-distal axis;

a ram within the housing, movable in a distal direction;

a user-operable push button moveable along the proximal-distal axis relative to the housing, the push button including a push button slot at a distal portion of the push button;

a crank arm having a pawl tooth, a pivot point, and a crank arm engagement member slideably engageable with the push button slot such that movement of the push button causes the crank arm engagement member to move along the push button slot, causing rotation of the crank arm about the pivot point;

a ratchet gear having a first set of teeth releasably engageable with the pawl tooth and a second set of teeth releaseably engageable with the ram, wherein engagement of the pawl tooth with the first set of teeth of the ratchet gear causes the ratchet gear to rotate, causing the ram to distally advance relative to the housing; and

an anti-reverse mechanism including;

at least one housing ratchet integrally formed on an internal surface of the housing; and

a flexible column integrally formed on and extending from a distal portion of the push button, the flexible column having a flexible column protrusion at a proximal end thereof,

wherein as the push button moves along the proximal-distal axis, the flexible column protrusion engages the housing ratchet and restricts movement of the push button to one direction during a resetting motion.

2. The dispensing mechanism of claim 1, wherein the flexible column protrusion is almond shaped.

3. The dispensing mechanism of claim 1, wherein the ram includes at least two sets of teeth.

4. The dispensing mechanism of claim 3, wherein at least one set of teeth has involute spur rack geometry.

5. The dispensing mechanism of claim 3, wherein a first set of ram teeth are configured to engage the second set of teeth of the ratchet gear, and a second set of ram teeth are configured to engage a housing protrusion, the housing protrusion being integrally formed within the housing and configured to facilitate movement of the ram in one direction.

6. The dispensing mechanism of claim 5, wherein first set of ram teeth and second set of teeth of the ratchet gear have similar corresponding involute gear teeth geometry.

7. The dispensing mechanism of claim 1, wherein the push button slot is oriented at an oblique angle with respect to the proximal-distal axis.

8. The dispensing mechanism of claim 1, wherein a push button slot has a portion that is oriented at an oblique angle with respect to the proximal-distal axis and a portion that oriented parallel to the proximal-distal axis.

9. The dispensing mechanism of claim 1, wherein at least one of the first set of teeth and the second set of teeth of ratchet gear control the dose amount.

10. An injector comprising:

the dispensing mechanism of claim 1;

a cartridge disposed within the housing;

a plunger disposed in the cartridge to seal a medicament therein, wherein the ram is associated with the plunger for forcing the plunger in a distal direction for ejecting a dose of medicament; and

a needle in fluid communication with the cartridge for injecting the doses into a patient.

11. The injector of claim 10, wherein the medicament includes a parathyroid hormone.

12. The injector of claim 11, wherein the parathyroid hormone is teriparatide.

13. The injector of claim 10, wherein the medicament includes glucagon-like peptide receptor agonists.

14. The injector of claim 13, wherein the glucagon-like peptide receptor agonist is exenatide.

15. The injector of claim 13, wherein the glucagon-like peptide receptor agonist is liraglutide.

16. A dispensing mechanism, comprising:

a housing having a proximal-distal axis;

a ram within the housing, movable in a distal direction;

a user-operable push button moveable along the proximal-distal axis relative to the housing, the push button including a push button slot at a distal portion of the push button;

a V-shaped crank arm having a pawl tooth, a pivot point, and a crank arm engagement member slideably engageable with the push button slot such that movement of the push button causes the crank arm engagement member to move along the push button slot, causing rotation of the crank arm about the pivot point; and

a ratchet gear having a first set of teeth releasably engageable with the pawl tooth and a second set of teeth releaseably engageable with the ram, wherein engagement of the pawl tooth with the first set of teeth of the ratchet gear causes the ratchet gear to rotate, causing the ram to distally advance relative to the housing,

wherein the crank arm is rotatable about a pivot axis extending through the pivot point, the pivot axis being generally perpendicular to the proximal-distal axis, and

wherein the ratchet gear is rotatable about the pivot axis.

17. The dispensing mechanism of claim 16, further comprising an anti-reverse mechanism including:

at least one housing ratchet integrally formed on an internal surface of the housing; and

a flexible column integrally formed on and extending from a distal portion of the push button, the flexible column having a flexible column protrusion at a proximal end thereof,

wherein as the push button moves along the proximal-distal axis, the flexible column protrusion engages the housing ratchet and restricts movement of the push button to one direction during a resetting motion.

18. The dispensing mechanism of claim 17, wherein the flexible column protrusion is almond shaped.