Cortical potential monitoring

• US 9,707,396 B2
• Filed: 10/25/2013
• Issued: 07/18/2017
• Est. Priority Date: 06/21/2013
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Su, Xin, Nelson, Dwight E.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Kimball, Jeremiah
• Application Number:
  US14/063,919
• Publication Number:
  US 20140378941A1
• Time in Patent Office: 1,362 Days
• Field of Search: 607115, 607 41, 600544
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/383 Somatosensory stimuli, e.g. electric stimulation
• CPC Class Codes: A61B 5/4255 Intestines, colon or appendix
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/37241 providing test stimulations

Abstract

Techniques, devices, and systems may include screening effective therapies using cortical evoked potentials. In one example, a system may be configured to receive a first sensed cortical evoked potential of a patient that occurred in response to an induced sensation at an anatomical region different from a brain region of the patient and receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves associated with the anatomical region. The electrical stimulation may be at least partially defined by a set of therapy parameter values. The system may also compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential and determine, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region.

Claims

1. A method comprising:

receiving a first sensed cortical evoked potential of a patient that occurred in response to a sensation induced at an anatomical region of the patient different from a brain region of the patient;

receiving a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves that innervate the anatomical region, wherein the electrical stimulation is at least partially defined by a set of therapy parameter values;

comparing, by one or more processors, a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential;

determining, based on the comparison and by the one or more processors, efficacy of a therapy configured to treat a condition associated with the anatomical region; and

controlling, based on the determination and by the one or more processors, delivery of the therapy to the one or more nerves that innervate the anatomical region.

2. The method of claim 1, further comprising:

controlling a sensing system to sense, from the brain region of the patient, the first cortical evoked potential occurring in response to the sensation induced at the anatomical region;

controlling a medical device to deliver the electrical stimulation to the one or more nerves that innervate the anatomical region; and

controlling the sensing system to sense, in response to controlling delivery of the electrical stimulation, the second cortical evoked potential from the brain region of the patient.

3. The method of claim 2, wherein controlling the sensing system to sense the first and second cortical evoked potentials comprises controlling the sensing system to sense the first and second cortical evoked potentials via one of electroencephalography, magenetoencephalography, functional magnetic resonance imaging, positron emission tomography, or direct recording by electrodes.

4. The method of claim 1, wherein determining efficacy of the therapy comprises indicating the therapy will be effective in response to determining that a difference between the first and second values of the characteristic is greater than an efficacy threshold.

5. The method of claim 1, wherein the set of therapy parameter values is one set of a plurality of sets of therapy parameter values, and wherein the method further comprises:

for each set of the plurality of sets of therapy parameter values, controlling delivery of electrical stimulation at least partially defined by the respective set of therapy parameter values;

responsive to the delivery of electrical stimulation defined by each of the respective sets of therapy parameter values, sensing a respective cortical evoked potential from the brain region of the patient;

for each of the respective cortical evoked potentials, comparing a respective value of the characteristic of the cortical evoked potential to the first value of the characteristic of the first sensed cortical evoked potential;

determining, based on the comparisons of the values of the characteristic of the respective cortical evoked potential to the first value of the characteristic of the first sensed cortical evoked potential, the cortical evoked potential with the value of the characteristic having a greatest difference from the first value of the characteristic of the first sensed cortical evoked potential; and

selecting, for electrical stimulation therapy, the set of therapy parameter values for which the determined respective cortical evoked potential was sensed.

6. The method of claim 1, wherein the characteristic is one of an amplitude of the evoked potential, a duration of the evoked potential, or a latency between stimulation delivery and the evoked potential.

7. The method of claim 1, wherein the set of therapy parameter values comprises a pulse frequency, and wherein the pulse frequency is selected from a range between 0.1 Hertz (Hz) and 25 Hz.

8. The method of claim 1, wherein the therapy is the electrical stimulation defined by the set of therapy parameter values, and wherein the method further comprises delivering, by an implantable medical device, the electrical stimulation to the one or more nerves that innervate the anatomical region.

9. The method of claim 1, wherein the therapy is a pharmaceutical therapy.

10. The method of claim 1, wherein the one or more nerves comprise one of a second sacral nerve or a third sacral nerve.

11. The method of claim 1, wherein the condition is fecal incontinence and the anatomical region is the rectum.

12. A system comprising:

one or more processors configured to;

receive a first sensed cortical evoked potential of a patient that occurred in response to a sensation induced at an anatomical region of the patient different from a brain region of the patient;

receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves that innervate the anatomical region, wherein the electrical stimulation is at least partially defined by a set of therapy parameter values;

compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential;

determine, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region; and

control, based on the determination, delivery of the therapy to the one or more nerves that innervate the anatomical region.

13. The system of claim 12, further comprising:

a therapy delivery module configured to deliver the electrical stimulation to the one or more nerves that innervate the anatomical region; and

a sensing system configured to;

sense, from the brain region of the patient, the first cortical evoked potential occurring in response to the induced sensation at the anatomical region; and

sense the second cortical evoked potential from the brain region of the patient.

14. The system of claim 13, wherein the sensing system is configured to sense the first and second cortical evoked potentials via one of electroencephalography, magenetoencephalography, functional magnetic resonance imaging, positron emission tomography, or direct recording by electrodes.

15. The system of claim 12, wherein the one or more processors are configured to:

determine that a difference between the first and second values of the characteristic is greater than an efficacy threshold; and

responsive to the determination, indicate the therapy will be effective.

16. The system of claim 12, wherein the set of therapy parameter values is one set of a plurality of sets of therapy parameter values, and wherein the system further comprises:

a therapy control module configured to, for each set of the plurality of sets of therapy parameter values, control delivery of electrical stimulation at least partially defined by the respective set of therapy parameter values; and

a sensing system configured to, responsive to the delivery of electrical stimulation defined by each of the respective sets of therapy parameter values, sense a respective cortical evoked potential from the brain region of the patient, wherein the one or more processors are configured to;

for each of the respective cortical evoked potentials, compare a respective value of the characteristic of the cortical evoked potential to the first value of the characteristic of the first sensed cortical evoked potential;

determine, based on the comparisons of the values of the characteristic of the respective cortical evoked potential to the first value of the characteristic of the first sensed cortical evoked potential, the cortical evoked potential with the value of the characteristic having a greatest difference from the first value of the characteristic of the first sensed cortical evoked potential; and

select, for electrical stimulation therapy, the set of therapy parameter values for which the determined cortical evoked potential was sensed.

17. The system of claim 12, wherein the characteristic comprises one of an amplitude of the evoked potential, a duration of the evoked potential, and or a latency between stimulation delivery and the evoked potential.

18. The system of claim 12, wherein the set of therapy parameter values comprises a pulse frequency, and wherein the pulse frequency is selected from a range between 0.1 Hz and 25 Hz.

19. The system of claim 12, wherein the therapy is the electrical stimulation defined by the set of therapy parameter values, and the system further comprising an implantable medical device configured to deliver the electrical stimulation to the one or more nerves that innervate the anatomical region.

20. The system of claim 12, wherein the one or more nerves comprise one of a second sacral nerve or a third sacral nerve.

21. The system of claim 12, wherein the condition is fecal incontinence and the anatomical region is the rectum.

22. A system comprising:

means for receiving a first sensed cortical evoked potential of a patient that occurred in response to a sensation induced at an anatomical region of the patient different from a brain region of the patient;

means for receiving a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves that innervate the anatomical region, wherein the electrical stimulation is at least partially defined by a set of therapy parameter values;

means for comparing a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential;

means for determining, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region; and

means for controlling, based on the determination, delivery of the therapy to the one or more nerves that innervate the anatomical region.

23. A non-transitory computer-readable storage medium comprising instructions that, when executed by one or more processors, causes the one or more processors to:

receive a first sensed cortical evoked potential of a patient that occurred in response to a sensation induced at an anatomical region of the patient different from a brain region of the patient;

receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves that innervate the anatomical region, wherein the electrical stimulation is at least partially defined by a set of therapy parameter values;

compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential;

determine, based on the comparison, efficacy or a therapy configured to treat a condition associated with the anatomical region; and

control, based on the determination, delivery of the therapy to the one or more nerves that innervate the anatomical region.