Microwave antenna apparatus, systems, and methods for localizing markers or tissue structures within a body

• US 9,713,437 B2
• Filed: 01/27/2014
• Issued: 07/25/2017
• Est. Priority Date: 01/26/2013
• Status: Active Grant

• Current Assignee: Cianna Medical Inc. (Merit Medical Systems, Inc.)
• Original Assignee: Cianna Medical Inc. (Merit Medical Systems, Inc.)
• Inventors: Greene, John E., Fullerton, Larry W., Nguyen, Tommy G., Chi Sing, Eduardo
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): COX, THADDEUS B
• Application Number:
  US14/165,253
• Publication Number:
  US 20140309522A1
• Time in Patent Office: 1,275 Days
• CPC Class Codes: A61B 2034/2048 using an accelerometer or inertia sensor
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3975 active
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 2090/3991 having specific anchoring means to fixate the marker to the tissue, e.g. hooks
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 5/6847 mounted on an invasive device
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers

Abstract

Apparatus, systems, and methods are provided for localizing lesions within a patient'"'"'s body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient'"'"'s skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.

Claims

1. A system for localization of a target tissue region within a patient'"'"'s body, comprising:

a probe comprising one or more antennas for transmitting electromagnetic signals into a patient'"'"'s body and receiving reflected signals from the patient'"'"'s body, the probe further comprising a light source for delivering light energy pulses into a patient'"'"'s body substantially simultaneously with transmitting the electromagnetic signals; and

a passive tag sized for implantation within a patient'"'"'s body, the tag comprising an energy converter configured to transform the light energy pulses from the light source into electrical energy, and a switch coupled to the energy converter such that the energy pulses cause the switch to open and close to modulate the electromagnetic signals from the probe reflected by the tag.

2. The system of claim 1, wherein the switch comprises a field effect transistor (FET) or a Schottky diode.

3. The system of claim 2, wherein the tag comprises a pair of elongate members coupled to terminals of the FET or Schottky diode to provide the antenna.

4. The system of claim 1, wherein the energy converter comprises one or more photosensitive diodes configured to convert light from the light source to generate a voltage to open and close the switch.

5. The system of claim 4, wherein the one or more photosensitive diodes comprise multiple diodes arranged orthogonally relative to one another.

6. The system of claim 1, wherein the probe comprises a tip configured for placement adjacent a patient'"'"'s body, and wherein the one or more antennas comprise a bowtie transmit antenna in the tip to transmit a transmit signal into the body, and a bowtie receive antenna in the tip to receive a receive signal that is reflected from the tag, the transmit and receive antennas comprising bowtie antenna elements configured as a Maltese cross, the antenna elements coupled to an element for impedance matching tissue of the patient'"'"'s body.

7. The system of claim 6, wherein the probe further comprises at least one processor coupled to the transmit and receive antennas to determine a distance from the tip of the probe to the tag based at least in part on the transmit and receive signals, and a display to present information representing the distance from the tip of the probe to the tag.

8. The system of claim 7, further comprising an accelerometer within the probe to measure an angle the probe is tilted in reference to the tag, and wherein the at least one processor is further configured to determine a location of the tag in relation to the tip of the probe by using a difference in time and the tilt angle of the probe.

9. The system of claim 6, wherein the element for impedance matching tissue comprises a ceramic disk and wherein the antenna elements comprise material on a top surface of the ceramic disk.

10. The system of claim 6, further comprising shielding surrounding the tip to shield the transmit and receive antennas.

11. The system of claim 1, wherein the probe comprises:

a housing including a tip for contacting tissue;

a ceramic disk attached to the tip comprising a first surface for contacting tissue when the tip is placed in contact with the tissue;

a transmit antenna to transmit a transmit signal into the body, and a receive antenna to receive a receive signal that is reflected from the tag, the transmit and receive antennas comprising antenna elements arranged as a Maltese cross on a second surface of the ceramic disk opposite the first surface; and

a Faraday shield on the tip to shield the transmit and receive antennas.

12. A method for localization of a target tissue region within a patient'"'"'s body, comprising:

implanting a tag within a patient'"'"'s body;

placing a tip of a probe adjacent the patient'"'"'s body oriented towards the tag; and

activating the probe to a) transmit electromagnetic signals into the patient'"'"'s body, b) receive reflected signals from the patient'"'"'s body, and c) substantially simultaneously with transmitting the electromagnetic signals, deliver light pulses into the patient'"'"'s body such that the tag transforms the light pulses into electrical energy to open and close a switch in the tag to modulate the electromagnetic signals from the probe reflected by the tag.

13. The method of claim 12, wherein the probe comprises a transmit antenna in the tip to transmit the electromagnetic signals into the body, and a receive antenna in the tip to receive the reflected signals from the tag, wherein the transmit antenna and the receive antenna together form a Maltese cross antenna.

14. The method of claim 13, wherein a ceramic element is mounted on top of the transmit antenna and the receive antenna for impedance matching.

15. The method of claim 12, wherein the method further comprises:

measuring, by an accelerometer on the probe, an angle the probe is tilted in reference to the tag; and

determining, by at least one processor coupled to the accelerometer, a location of the tag in relation to the tip of the probe by using a difference in time and the tilt angle of the probe.

16. The method of claim 12, wherein the tag comprises an energy converter that transforms the light pulses into electrical energy such that the light pulses cause the switch to open and close to modulate the electromagnetic signals from the probe reflected by the tag.

17. The method of claim 16, wherein the energy converter comprises one or more photosensitive diodes configured to convert the light pulses to generate a voltage to open and close the switch.

18. A method for localization of a target tissue region within a patient'"'"'s body, comprising:

implanting a tag within a patient'"'"'s body;

placing a probe adjacent the patient'"'"'s body oriented towards the tag; and

activating the probe to a) transmit electromagnetic signals into the patient'"'"'s body, b) receive reflected signals from the patient'"'"'s body, and c) substantially simultaneously with transmitting the electromagnetic signals, deliver light pulses into the patient'"'"'s body such that the tag transforms the light pulses into electrical energy to open and close a switch in the tag to modulate the electromagnetic signals from the probe reflected by the tag and received by the probe as reflected signals.

19. A system for localization of a target tissue region within a patient'"'"'s body, comprising:

a probe comprising one or more antennas for transmitting electromagnetic signals into a patient'"'"'s body and receiving reflected signals from the patient'"'"'s body, the probe further comprising an energy source for delivering energy pulses into a patient'"'"'s body; and

a passive tag sized for implantation within a patient'"'"'s body, the tag comprising an energy converter configured to transform the energy pulses from the energy source into electrical energy, and a switch coupled to the energy converter such that the energy pulses cause the switch to open and close to modulate the electromagnetic signals from the probe reflected by the tag,

wherein the probe comprises a tip configured for placement adjacent a patient'"'"'s body, and wherein the one or more antennas comprise a bowtie transmit antenna in the tip to transmit a transmit signal into the body, and a bowtie receive antenna in the tip to receive a receive signal that is reflected from the tag, the transmit and receive antennas comprising bowtie antenna elements configured as a Maltese cross, the antenna elements coupled to an element for impedance matching tissue of the patient'"'"'s body,

wherein the element for impedance matching tissue comprises a ceramic disk and wherein the antenna elements comprise material on a top surface of the ceramic disk, and

wherein the ceramic disk comprises slots between adjacent antenna elements to substantially isolate the antenna elements from one another.

20. A system for localization of a target tissue region within a patient'"'"'s body, comprising:

a probe comprising one or more antennas for transmitting electromagnetic signals into a patient'"'"'s body and receiving reflected signals from the patient'"'"'s body, the probe further comprising an energy source for delivering energy pulses into a patient'"'"'s body; and

a passive tag sized for implantation within a patient'"'"'s body, the tag comprising an energy converter configured to transform the energy pulses from the energy source into electrical energy, and a switch coupled to the energy converter such that the energy pulses cause the switch to open and close to modulate the electromagnetic signals from the probe reflected by the tag,

wherein the probe comprises;

a housing including a tip for contacting tissue;

a ceramic disk attached to the tip comprising a first surface for contacting tissue when the tip is placed in contact with the tissue;

a transmit antenna to transmit a transmit signal into the body, and a receive antenna to receive a receive signal that is reflected from the tag, the transmit and receive antennas comprising antenna elements arranged as a Maltese cross on a second surface of the ceramic disk opposite the first surface; and

a Faraday shield on the tip to shield the transmit and receive antennas, and

wherein the antenna elements comprises two pairs of antenna elements offset from one another by ninety degrees, and wherein the ceramic disk comprises slots between adjacent antenna elements to substantially isolate the antenna elements from one another.

21. A system for localization of a target tissue region within a patient'"'"'s body, comprising:

a probe comprising one or more antennas for transmitting electromagnetic signals into a patient'"'"'s body and receiving reflected signals from the patient'"'"'s body, the probe further comprising an energy source for delivering energy pulses into a patient'"'"'s body; and

a passive tag sized for implantation within a patient'"'"'s body, the tag comprising an energy converter configured to transform the energy pulses from the energy source into electrical energy, and a switch coupled to the energy converter such that the energy pulses cause the switch to open and close to modulate the electromagnetic signals from the probe reflected by the tag,

wherein the probe comprises;

a housing including a tip for contacting tissue;

a ceramic disk attached to the tip comprising a first surface for contacting tissue when the tip is placed in contact with the tissue;

a transmit antenna to transmit a transmit signal into the body, and a receive antenna to receive a receive signal that is reflected from the tag, the transmit and receive antennas comprising antenna elements arranged as a Maltese cross on a second surface of the ceramic disk opposite the first surface;

a Faraday shield on the tip to shield the transmit and receive antennas; and

a region filled with air adjacent the second surface configured to minimize lost energy away from the tissue contacted by the first surface.

22. A system for localization of a target tissue region within a patient'"'"'s body, comprising:

a probe comprising one or more antennas for transmitting electromagnetic signals into a patient'"'"'s body and receiving reflected signals from the patient'"'"'s body, the probe further comprising a light source for delivering light pulses into a patient'"'"'s body substantially simultaneously with transmitting the electromagnetic signals; and

a passive tag sized for implantation within a patient'"'"'s body, the tag comprising a field effect transistor (FET), one or more photosensitive diodes coupled in series across a source and a gate of the FET to convert light pulses received from the light source to generate a voltage to open and close the FET, and a pair of elongate core members coupled to a drain and the source of the FET to provide an antenna, the FET configured to open and close to modulate signals reflected by the antenna back to the probe.

23. The system of claim 22, wherein the probe further comprises at least one processor coupled to the one or more antennas to determine a distance from the probe to the tag based at least in part on the transmit and receive signals, the at least one processor configured to perform a subtraction function based on the modulated signals when the FET is open and closed to determine the distance.