Transdermal estrogen device and delivery

CAFC
  • US 9,730,900 B2
  • Filed: 07/20/2012
  • Issued: 08/15/2017
  • Est. Priority Date: 07/10/2008
  • Status: Active Grant
First Claim
Patent Images

1. A method for administering estradiol, comprising applying to the skin or mucosa of a subject in need thereof a monolithic transdermal drug delivery system consisting of (i) a backing layer and (ii) a single adhesive polymer matrix layer defining an active surface area and comprising an adhesive polymer matrix comprising estradiol as the only drug, wherein the polymer matrix has a coat weight of greater than about 10 mg/cm2 and includes greater than 0.156 mg/cm2 estradiol, and the system achieves an estradiol flux of from about 0.0125 to about 0.05 mg/cm2/day, based on the active surface area.

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