Systems and methods for determining respiration information from a photoplethysmograph

• US 9,737,266 B2
• Filed: 08/28/2015
• Issued: 08/22/2017
• Est. Priority Date: 09/23/2011
• Status: Active Grant

• Current Assignee: Nellcor Puritan Bennett Ireland
• Original Assignee: Nellcor Puritan Bennett Ireland
• Inventors: Dripps, James, Ochs, James, Addison, Paul S., Watson, James
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TRAN, THO Q
• Application Number:
  US14/839,659
• Publication Number:
  US 20150366516A1
• Time in Patent Office: 725 Days
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

A signal representing physiological information may include information related to respiration. A patient monitoring system may generate a plurality of autocorrelation sequences from the signal and combine the autocorrelation sequences to generate a combined autocorrelation sequence. The combined autocorrelation sequence may be analyzed to identify one or more peaks that may correspond to respiration information. Respiration information such as respiration rate may be determined based on the one or more peaks.

Claims

1. A pulse oximetry monitoring system for processing physiological information of a subject, comprising:

a pulse oximeter comprising;

a pulse oximetry sensor input configured to be coupled to a pulse oximetry sensor, the pulse oximetry sensor configured to detect light attenuated by the subject and generate a photoplethysmograph (PPG) signal, which is received by the pulse oximetry sensor input;

a microprocessor coupled to the pulse oximetry sensor input and configured to;

generate a plurality of morphology signals based on the PPG signal, wherein each of the plurality of morphology signals is indicative of a respective morphology of the PPG signal,

generate a first autocorrelation sequence for a first morphology signal of the plurality of morphology signals,

generate a second autocorrelation sequence for a second morphology signal of the plurality of morphology signals,

combine at least the first autocorrelation sequence and the second autocorrelation sequence into a combined autocorrelation sequence, and

determine a respiration rate from the combined autocorrelation sequence; and

a display on which the respiration rate is displayed.

2. The pulse oximetry monitoring system of claim 1, wherein the microprocessor is further configured to calculate a combination weight for each autocorrelation sequence of the plurality of autocorrelation sequences and to generate the combined autocorrelation sequence based at least on the combination weights of the first autocorrelation sequence and the second autocorrelation sequence.

3. The pulse oximetry monitoring system of claim 1, wherein the microprocessor is further configured to generate a confidence value based on the combined autocorrelation sequence.

4. The pulse oximetry monitoring system of claim 3, wherein the confidence value is based on a residual sum of a best fit of the combined autocorrelation sequence.

5. The pulse oximetry monitoring system of claim 3, wherein the confidence value is based on a time distribution of the combined autocorrelation sequence.

6. The pulse oximetry monitoring system of claim 1, wherein the plurality of morphology signals comprises at least one of down signal, kurtosis signal, delta of second derivative signal, skew signal, center of gravity signal, and area of a pulse signal.

7. The pulse oximetry monitoring system of claim 1, wherein the determining the respiration rate from the combined autocorrelation sequence comprises performing a wavelet transform of the combined autocorrelation sequence.

8. The pulse oximetry monitoring system of claim 1, wherein the combined autocorrelation sequence is based on a signal age of the first autocorrelation sequence and a signal age of the second autocorrelation sequence.

9. A method for processing physiological information of a subject by a pulse oximeter, comprising:

receiving, using a pulse oximeter, a photoplethysmograph (PPG) signal from a pulse oximetry sensor, wherein the pulse oximetry sensor is configured to detect light attenuated by the subject;

generating, using the pulse oximeter, a plurality of morphology signals based on the PPG signal, wherein each of the plurality of morphology signals is indicative of a respective morphology of the PPG signal;

generating, using the pulse oximeter, a first autocorrelation sequence for a first morphology signal of the plurality of morphology signals;

generating, using the pulse oximeter, a second autocorrelation sequence for a second morphology signal of the plurality of morphology signals;

combining, using the pulse oximeter, at least the first autocorrelation sequence and the second autocorrelation sequence into a combined autocorrelation sequence;

determining, using the pulse oximeter, a respiration rate from the combined autocorrelation sequence; and

displaying, using a display, the respiration rate.

10. The method of claim 9, further comprising:

calculating, using the pulse oximeter, a combination weight for each autocorrelation sequence of the plurality of autocorrelation sequences; and

generating, using the pulse oximeter, the combined autocorrelation sequence based at least on the combination weights of the first autocorrelation sequence and the second autocorrelation sequence.

11. The method of claim 9, further comprising generating, using the pulse oximeter, a confidence value based on the combined autocorrelation sequence.

12. The method of claim 11, wherein the confidence value is based on a residual sum of a best fit of the combined autocorrelation sequence.

13. The method of claim 11, wherein the confidence value is based on a time distribution of the combined autocorrelation sequence.

14. The method of claim 9, wherein the plurality of morphology signals comprises at least one of down signal, kurtosis signal, delta of second derivative signal, skew signal, center of gravity signal, and area of a pulse signal.

15. The method of claim 9, wherein determining the respiration rate from the combined autocorrelation sequence comprises performing a wavelet transform of the combined autocorrelation sequence.

16. The method of claim 9, wherein the combined autocorrelation sequence is based on a signal age of the first autocorrelation sequence and a signal age of the second autocorrelation sequence.

17. A non-transitory computer-readable medium for use in processing physiological information of a subject, the non-transitory computer-readable medium comprising:

computer program instructions recorded thereon for causing a pulse oximeter to;

receive a photoplethysmograph (PPG) signal from a pulse oximetry sensor, wherein the pulse oximetry sensor is configured to detect light attenuated by the subject;

generate a plurality of morphology signals based on the PPG signal, wherein each of the plurality of morphology signals is indicative of a respective morphology of the PPG signal;

generate a first autocorrelation sequences for a first morphology signal of the plurality of morphology signals;

generate a second autocorrelation sequence for a second morphology signal of the plurality of morphology signals;

combine at least the first autocorrelation sequence and the second autocorrelation sequence into a combined autocorrelation sequence;

determine a respiration rate from the combined autocorrelation sequence; and

display the respiration rate on a display.

18. The non-transitory computer-readable medium of claim 17, further comprising computer program instructions recorded thereon for causing the pulse oximeter to:

calculate a combination weight for each autocorrelation sequence of the plurality of autocorrelation sequences; and

generate the combined autocorrelation sequence based at least on the combination weights of the first autocorrelation sequence and the second autocorrelation sequence.

19. The non-transitory computer-readable medium of claim 17, wherein the plurality of morphology signals comprises at least one of down signal, kurtosis signal, delta of second derivative signal, skew signal, center of gravity signal, and area of a pulse signal.

20. The non-transitory computer-readable medium of claim 17, wherein the combined autocorrelation sequence is based on a signal age of the first autocorrelation sequence and a signal age of the second autocorrelation sequence.