Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients

• US 9,750,923 B2
• Filed: 11/19/2015
• Issued: 09/05/2017
• Est. Priority Date: 11/19/2014
• Status: Active Grant

• Current Assignee: Veloce Corp.
• Original Assignee: Veloce Corp.
• Inventors: Niichel, Robert, McWilliams, Kevin, English, John, Torbati, Amir H., Yakacki, Christopher M.
• Primary Examiner(s): Bosworth, Kami A
• Application Number:
  US14/946,478
• Publication Number:
  US 20160136104A1
• Time in Patent Office: 656 Days
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

Claims

1. A consumable capsule having an outer surrounding sidewall, comprising:

a signal receiving section comprising at least one coil configured to receive a wireless signal;

a control section configured to condition the wireless signal received by the at least one coil into a trigger signal for the consumable capsule;

a compartment section comprising at least one capsule compartment movably sealed by a stimuli responsive actuator, the compartment section being configured to activate the stimuli responsive actuator in response to the trigger signal from the control section to allow for release of an active ingredient contained in the at least one capsule compartment into an external environment

wherein the stimuli responsive actuator extends around the entire circumference of the outer surrounding sidewall and activation of the stimuli responsive actuator causes the stimuli responsive actuator to change shape in at least a radial direction and a longitudinal direction.

2. The consumable capsule of claim 1, wherein the at least one stimuli responsive actuator comprises azobenzene incorporated in a liquid-crystalline elastomer.

3. The consumable capsule of claim 1, wherein the compartment section further comprises a light source configured to emit light based at least in part on the trigger signal, and wherein the stimuli responsive actuator is activated based at least in part on the emitted light.

4. The consumable capsule of claim 1, wherein the compartment section comprises at least two capsule compartments, the compartment section configured to simultaneously open the at least two capsule compartments.

5. The consumable capsule of claim 1, wherein the compartment section comprises a plurality of capsule compartments, the compartment section being configured to sequentially open each capsule compartment of the plurality of capsule compartments.

6. The consumable capsule of claim 1, wherein the control section comprises:

at least one rectifying circuit for rectifying the wireless signal, the rectifying circuit comprising at least one light emitting diode (LED), and

wherein the at least one LED is configured to activate the stimuli responsive actuator.

7. A consumable capsule having an outer surrounding sidewall, comprising:

a signal receiving section comprising at least one coil configured to receive a wireless signal;

a control section configured to condition the wireless signal received by the at least one coil into a trigger signal for the consumable capsule;

a compartment section comprising at least one capsule compartment movably sealed by a stimuli responsive actuator, the compartment section being configured to activate the stimuli responsive actuator in response to the trigger signal from the control section to allow for release of an active ingredient contained in the at least one capsule compartment into an external environment

wherein the stimuli responsive actuator extends around the entire circumference of the outer surrounding sidewall and activation of the stimuli responsive actuator causes the stimuli responsive actuator to separate along a seam extending in a direction generally parallel to a longitudinal axis of the capsule.

8. The consumable capsule of claim 7, wherein the at least one stimuli responsive actuator comprises azobenzene incorporated in a liquid-crystalline elastomer.

9. The consumable capsule of claim 7, wherein the compartment section further comprises a light source configured to emit light based at least in part on the trigger signal, and wherein the stimuli responsive actuator is activated based at least in part on the emitted light.

10. The consumable capsule of claim 7, wherein the compartment section comprises at least two capsule compartments, the compartment section configured to simultaneously open the at least two capsule compartments.

11. The consumable capsule of claim 7, wherein the compartment section comprises a plurality of capsule compartments, the compartment section being configured to sequentially open each capsule compartment of the plurality of capsule compartments.

12. The consumable capsule of claim 7, wherein the control section comprises:

at least one rectifying circuit for rectifying the wireless signal, the rectifying circuit comprising at least one light emitting diode (LED), and

wherein the at least one LED is configured to activate the stimuli responsive actuator.