Low oxygen in vivo analyte sensor

• US 9,757,061 B2
• Filed: 09/01/2015
• Issued: 09/12/2017
• Est. Priority Date: 01/17/2006
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Shults, Mark, Rhodes, Rathbun K., Updike, Stuart J., Brauker, James H.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): MESSERSMITH, ERIC J
• APPLICATION: US 20150374270A1
• Time in patent office: 742 Days
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Claims

1. A transcutaneous continuous sensor device for measuring a concentration of glucose in a biological fluid of a host, the device comprising:

a glucose sensor comprising an electrode and a membrane comprising a first domain and a second domain, wherein the first domain comprises an enzyme configured to react with glucose, wherein the second domain comprises polyurethaneurea;

wherein the glucose sensor is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.6 mg/L.

2. The device of claim 1, wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.4 mg/L.

3. The device of claim 1, wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.15 mg/L.

4. The device of claim 1, wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.1 mg/L.

5. The device of claim 1, wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.05 mg/L.

6. The device of claim 1, wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.02 mg/L.

7. The device of claim 1, wherein the device is configured to have an operable life implanted within a host of at least about one week.

8. The device of claim 1, further comprising sensor electronics operably connected to the electrode, wherein the sensor electronics is configured to measure a current produced by the electrode.