Recipe for in-situ gel, and implant, drug delivery system formed thereby

  • US 9,757,330 B2
  • Filed: 09/17/2014
  • Issued: 09/12/2017
  • Est. Priority Date: 10/18/2013
  • Status: Active Grant
First Claim
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1. A composition, comprisingat least one polymer,at least one gel prevention agent andat least one polar solvent,wherein a ratio of the polymer and the gel prevention agent is 1:



  • 1;

    200 by weight,wherein the gel prevention agent diffuses from the polymer when the composition is placed in an aqueous environment or a living tissue and thereby an in-situ gel is formed,wherein the polymer comprises a polymer with an upper critical solution temperature (UCST), biopolymer, synthetic ABA triblock copolymer, zwitterionic homopolymer or a combination thereof, andwherein the synthetic ABA triblock copolymer comprises a copolymer synthesized with N-(3-(methacryoylamino)propyl)-N,N-dimethyl-N-(3-sulfopropyl)ammonium hydroxide as the A block and 2-(2-methoxtethoxy) ethyl methacrylate as the B block, or wherein the zwitterionic homopolymer comprises phosphobetaines, sulfobetaines, carboxybetaines, or a combination thereof.

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