Control of circulatory assist systems

• US 9,757,502 B2
• Filed: 09/23/2011
• Issued: 09/12/2017
• Est. Priority Date: 09/24/2010
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories Incorporated)
• Original Assignee: TCI, LLC (Allient, Inc.)
• Inventors: Burke, David J., Bourque, Kevin
• Primary Examiner(s): Lee, Erica
• Application Number:
  US13/242,248
• Publication Number:
  US 20120078031A1
• Time in Patent Office: 2,181 Days
• Field of Search: None
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3365 Rotational speed
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/183 drawing blood from both ventricles, e.g. bi-ventricular assist devices [BiVAD]
• CPC Class Codes: A61M 60/232 Centrifugal pumps
• CPC Class Codes: A61M 60/237 the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/523 using blood flow data, e.g. from blood flow transducers
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed
• CPC Class Codes: A61M 60/562 for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow

Abstract

In one general aspect, a method includes measuring blood flow through a right rotary blood pump, measuring blood flow through a left rotary blood pump, and controlling a speed of one of the rotary blood pumps using a controller that calculates the speed of one of the rotary blood pumps based on the measured blood flow through the other rotary blood pump.

Claims

1. A blood pump system, comprising:

a first rotary blood pump configured to be connected to a patient'"'"'s left ventricle to pump blood from the left ventricle to the patient'"'"'s ascending aorta via a first outflow graft;

a second rotary blood pump configured to be connected to a patient'"'"'s right ventricle to pump blood from the right ventricle to the patient'"'"'s pulmonary system via a second outflow graft; and

a blood pump controller including;

an input interface configured to;

receive a first signal indicative of blood flow rate through a first rotary blood pump configured to be connected to a patient'"'"'s left ventricle and pump blood from the left ventricle to the patient'"'"'s ascending aorta via a first outflow graft; and

receive a second signal indicative of blood flow rate through a second rotary blood pump different from the first rotary blood pump and configured to be connected to the patient'"'"'s right ventricle and pump blood from the right ventricle to the patient'"'"'s pulmonary system via a second outflow graft; and

a processing unit configured to generate and transmit separate control signals to the first and second rotary blood pumps to adjust the speed of each of the first and second rotary blood pumps based on a target support level for the patient while maintaining a predetermined ratio between blood flow rate through the second rotary blood pump and blood flow rate through the first rotary blood pump.

2. The blood pump system of claim 1, wherein the processing unit is further configured to:

generate a target pulsatility index for the first rotary blood pump based on the target support level for the patient;

measure a pulsatility-index for the patient'"'"'s left ventricle; and

control the speed of the first rotary blood pump to minimize a difference between the measured pulsatility index for the left ventricle and the target pulsatility index for the first rotary blood pump.

3. The blood pump system of claim 2, wherein the measured pulsatility index indicates a load on the patient'"'"'s left ventricle experienced during contraction of the left ventricle.

4. The blood pump system of claim 2, wherein the measured pulsatility index (PI) is calculated by the processing unit over a control interval according to the following equation:

PI=(Qmax−

Qmin)/Qave, where Qmax is a maximum flow rate through the first rotary blood pump in the control interval, Qmin is a minimum flow rate through the first rotary blood pump in the control interval, and Qave is an average flow rate through the first pump over the control interval.

5. The blood pump system of claim 4, wherein the processing unit is further configured to:

control at least one of the first and second pumps to produce an artificially induced pulsatile blood flow; and

calculate the measured pulsatility index such that data influenced by artificial blood flow variations of the artificially induced pulsatile blood flow are excluded from the calculation of the measured pulsatility index.

6. The blood pump system of claim 2, wherein the processing unit is further configured to control the speed of the first rotary blood pump based on a detected heart rate so as to:

decrease the speed of the first rotary blood pump when the measured pulsatility index is below the target pulsatility index and the detected heart rate does not exceed a threshold heart rate;

maintain the speed of the first rotary blood pump when the measured pulsatility index is below the target pulsatility index and the detected heart rate exceeds the threshold heart rate; and

increase the speed of the first rotary blood pump when the measured pulsatility index is above the target pulsatility index.

7. The blood pump system of claim 1, wherein the processing unit is further configured to:

generate a target pulsatility index for the second rotary blood pump based on the target support level for the patient;

measure a pulsatility index for the patient'"'"'s right ventricle; and

control the speed of the second rotary blood pump to minimize a difference between the measured pulsatility index for the right ventricle and the target pulsatility index for the second rotary blood pump.

8. The blood pump system of claim 1, wherein the processing unit is configured to control at least one of the first and second rotary blood pumps to operate in a pulse mode that simulates a pressure change of natural physiologic pulse.

9. The blood pump system of claim 8, wherein controlling the rotary blood pump to operate in the pulse mode comprises:

increasing the operating speed of the rotary blood pump from a first speed to a second speed; and

decreasing the operating speed of the rotary blood pump from the second speed to a third speed that is greater than the first speed.

10. The blood pump system of claim 8, wherein controlling the rotary blood pump to operate in the pulse mode comprises:

operating the rotary blood pump at a first speed for a first period of time;

reducing the speed of the rotary blood pump from the first speed to a second speed;

operating the rotary blood pump at the second speed for a second period of time;

reducing the speed of the rotary blood pump from the second speed to a third speed;

operating the rotary blood pump at the third speed for a third period of time; and

increasing the speed of the rotary blood pump from the third speed to the first speed.

11. The blood pump system of claim 1, wherein the processing unit is further configured to alternately control at least one of the first and second rotary blood pumps between a pulse mode that simulates a pressure change of natural physiologic pulse and a continuous mode that does not simulate a pressure change of natural physiologic pulse.

12. The blood pump system of claim 11, wherein the processing unit is configured to control one of the first and second rotary blood pumps to operate in the pulse mode while controlling the other of the first and second rotary blood pumps to operate in the continuous mode.

13. The blood pump system of claim 1, wherein the processing unit is further configured to control the speed of the first pump based on a detected heart rate.

14. The blood pump system of claim 1, wherein the received signal indicating blood flow rate through the first rotary blood pump is indicative of a degree of cardiac unloading.

15. A method of controlling blood flow, comprising:

operating a first rotary blood pump connected to a patient'"'"'s left ventricle to pump blood from the left ventricle to the patient'"'"'s ascending aorta via a first outflow graft;

operating a second rotary blood pump connected to a patient'"'"'s right ventricle to pump blood from the right ventricle to the patient'"'"'s pulmonary system via a second outflow graft; and

separately controlling each of the first and second rotary blood pumps via a blood pump controller to provide a target support level for the patient while maintaining a predetermined ratio between blood flow rate through the second rotary blood pump and blood flow rate through the first rotary blood pump.

16. The method of claim 15, wherein:

the blood pump controller controls the speed of the second rotary blood pump such that the blood flow rate through the second rotary blood pump is less than the blood flow rate through the first rotary blood pump.

17. The method of claim 15 further comprising:

determining, by the blood pump controller, that the measured blood flow rate through the first pump has changed to a new first pump blood flow rate; and

adjusting, by the blood pump controller, the speed of second pump to maintain the predetermined ratio between the blood flow rate through the second rotary blood pump and the new first pump blood flow rate.

18. The method of claim 15 further comprising:

determining, by the blood pump controller, that the measured blood flow through one of the first and second rotary blood pumps exceeds a threshold; and

controlling, by the blood pump controller, the speed of each of the first and second rotary blood pumps such that the measured blood flow that exceeds the threshold is reduced below the threshold.

19. The method of claim 15, further comprising controlling, by the blood pump controller, one of the first and second rotary blood pumps to generate a rate of pressure change that simulates a pressure change of natural physiologic pulse.

20. The method of claim 19, wherein generation of the rate of pressure change that simulates a pressure change of natural physiologic pulse comprises:

increasing the operating speed of said one of the rotary blood pumps from a first speed to a second speed; and

decreasing the operating speed of the rotary blood pump from the second speed to a third speed that is greater than the first speed.

21. The method of claim 19, wherein generation of the rate of pressure change that simulates a pressure change of natural physiologic pulse comprises:

operating said one of the rotary blood pumps at a first speed for a first period of time;

reducing the speed of said one of the rotary blood pumps from the first speed to a second speed;

operating said one of the rotary blood pumps at the second speed for a second period of time;

reducing the speed of said one of the rotary blood pumps from the second speed to a third speed;

operating said one of the rotary blood pumps at the third speed for a third period of time; and

increasing the speed of said one of the rotary blood pumps from the third speed to the first speed.

22. The method of claim 19, comprising alternately controlling at least one of the first and second rotary blood pumps in a pulse mode that simulates a pressure change of natural physiologic pulse and a continuous mode that does not simulate a pressure change of natural physiologic pulse.

23. The method of claim 22, comprising controlling one of the first and second rotary blood pumps to operate in the pulse mode while controlling the other of the first and second rotary blood pumps to operate in the continuous mode.

24. The method of claim 15, further comprising:

generating, by the blood pump controller, a target pulsatility index for the first rotary blood pump based on the target support level for the patient;

measuring, by the blood pump controller, a pulsatility value for the patient'"'"'s left ventricle; and

controlling, by the blood pump controller, the speed of the first rotary blood pump to minimize a difference between the measured pulsatility index for the left ventricle and the target pulsatility index for the first rotary blood pump.

25. The method of claim 24, wherein the measured pulsatility index (PI) is calculated by the blood pump controller over a control interval according to the following equation:

PI=(Qmax−

Qmin)/Qave, where Qmax is a maximum flow rate through the first pump in the control interval, Qmin is a minimum flow rate through the first rotary blood pump in the control interval, and Qave is an average flow rate through the first rotary blood pump over the control interval.

26. The method of claim 24, further comprising:

controlling, by the blood pump controller, at least one of the first and second rotary blood pumps to produce an artificially induced pulsatile blood flow; and

calculating, by the blood pump controller, the measured pulsatility index such that data influenced by artificial blood flow variations of the artificially induced pulsatile blood flow are excluded from the calculation of the measured pulsatility index.

27. The method of claim 24, further comprising:

decreasing the speed of the first pump when the measured pulsatility index is below the target pulsatility index and the detected heart rate does not exceed a threshold heart rate;

maintaining the speed of the first pump when the measured pulsatility index is below the target pulsatility index and the detected heart rate exceeds the threshold heart rate; and

increasing the speed of the first pump when the measured pulsatility index is above the target pulsatility index.

28. The method of claim 15, comprising controlling the speed of the first pump based on a detected heart rate.

29. The method of claim 15, wherein measuring the blood flow rate through the first rotary blood pump comprises processing a signal indicative of a degree of cardiac unloading.