Interfering RNA molecules

  • US 9,758,784 B1
  • Filed: 05/08/2017
  • Issued: 09/12/2017
  • Est. Priority Date: 08/05/2002
  • Status: Active Grant
First Claim
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1. A double-stranded siRNA molecule against a target nucleic acid, wherein the double-stranded siRNA molecule comprises a first strand and a second strand,wherein the first strand comprises a first stretch that is complementary to the target nucleic acid,wherein the second strand comprises a second stretch that is complementary to the first stretch,wherein the first strand and the second strand form a double-stranded structure comprising the first stretch and the second stretch,wherein the double-stranded siRNA molecule is blunt ended on at least one end, andwherein each stretch consists of at least 15 and fewer than 30 ribonucleotides and wherein the first stretch and the second stretch each comprises contiguous alternating modified ribonucleotides, wherein the alternating modified ribonucleotides alternate with unmodified or differently modified ribonucleotides.

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