Combination of brimonidine and timolol for topical ophthalmic use

CAFC
  • US 9,770,453 B2
  • Filed: 02/22/2017
  • Issued: 09/26/2017
  • Est. Priority Date: 04/19/2002
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating a patient with glaucoma or ocular hypertension comprising topically administering twice daily to an affected eye a single composition comprising 0.2% w/v brimonidine tartrate and 0.68% w/v timolol maleate, wherein the method is as effective as the administration of 0.2% w/v brimonidine tartrate monotherapy three times per day and wherein the method reduces the incidence of one of more adverse events selected from the group consisting of conjunctival hyperemia, oral dryness, eye pruritus, allergic conjunctivitis, foreign body sensation, conjunctival folliculosis, and somnolence when compared to the administration of 0.2% w/v brimonidine tartrate monotherapy three times daily.

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