Analyte sensing biointerface

• US 9,788,766 B2
• Filed: 05/19/2014
• Issued: 10/17/2017
• Est. Priority Date: 04/15/2005
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Brauker, James H.
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US14/281,697
• Publication Number:
  US 20140303465A1
• Time in Patent Office: 1,247 Days
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. A transcutaneous continuous glucose sensor system, comprising:

a substantially planar sensor, the sensor comprising;

a first non-conductive layer;

a first conductive layer comprising a first electrode, wherein the first conductive layer is disposed over the first non-conductive layer;

a second non-conductive layer disposed over the first conductive layer;

a second conductive layer comprising a second electrode, wherein the second conductive layer is disposed over the second non-conductive layer;

a third non-conductive layer disposed over the second conductive layer;

a third conductive layer comprising a third electrode, wherein the third conductive layer is disposed over the third non-conductive layer;

wherein at least one of the first electrode, second electrode, or third electrode is a working electrode configured to measure a signal indicative of a glucose concentration;

a membrane disposed on at least a portion of the sensor; and

electronics electrically coupled to the working electrode.

2. The sensor of claim 1, wherein the membrane comprises an enzyme.

3. The sensor of claim 2, wherein the membrane further comprises a resistance domain disposed over the enzyme.

4. The sensor of claim 1, wherein the membrane further comprises a bioactive agent.

5. The sensor of claim 1, wherein the membrane is substantially planar.