Electrical treatment of bronchial constriction

• US 9,821,164 B2
• Filed: 07/31/2014
• Issued: 11/21/2017
• Est. Priority Date: 11/10/2005
• Status: Active Grant

• Current Assignee: Electrocore, Llc
• Original Assignee: Electrocore, Llc
• Inventors: Errico, Joseph P., Mendez, Steven, Simon, Bruce J., Pastena, James R., Hu, Hecheng, Ross, Arthur
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US14/448,357
• Publication Number:
  US 20140343565A1
• Time in Patent Office: 1,209 Days
• CPC Class Codes: A61N 1/0517 Esophageal electrodes
• CPC Class Codes: A61N 1/0519 Endotracheal electrodes
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters

Abstract

Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient'"'"'s neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.

Claims

1. A method of treating a medical disorder in a patient, the method comprising:

advancing an introducer through an incision in an outer skin surface of a neck of a patient to a target site at or near a vagus nerve of a patient;

introducing one or more electrodes through the introducer to the target site;

positioning the one or more electrodes adjacent the vagus nerve exterior to a carotid sheath of the vagus nerve;

generating an electrical impulse from a location exterior to the patient; and

transmitting the electrical impulse through the incision in the outer skin surface of the neck of the patient to the one or more electrodes such that the electrical impulse is applied to the vagus nerve, wherein the electrical impulse is sufficient to modulate the vagus nerve to treat the medical disorder, wherein the medical disorder is bronchoconstriction and the electrical impulse is sufficient to increase a forced expiratory volume in 1 second of the patient by a clinically significant amount in a period of time less than 6 hours.

2. The method of claim 1, wherein the electrical impulse has a frequency from 15 Hz to 50 Hz.

3. The method of claim 1, wherein the electrical impulse is insufficient to simulate efferent fibers of the vagus nerve.

4. The method of claim 1, wherein the electrical impulse is of an amplitude from 1 volt to 12 volts.

5. The method of claim 1, wherein the electrical impulse has a pulsed on-time from 50 microseconds to 500 microseconds.

6. The method of claim 1, wherein the electrical impulse has a pulsed on-time from 200 microseconds to 400 microseconds and an amplitude from 6 volts to 12 volts.

7. The method of claim 1, wherein the electrical impulse is sufficient to treat the medical disorder in the patient in less than 2 hours.

8. The method of claim 1, wherein the electrical impulse is sufficient to treat the medical disorder in the patient in less than 1 hour.

9. The method of claim 1, wherein the electrical impulse is sufficient to treat the medical disorder in the patient in less than 15 minutes.

10. The method of claim 1, wherein the electrical impulse has a pulsed on-time from 200 microseconds to 400 microseconds and an amplitude from 6 volts to 12 volts.

11. A device for treating a medical disorder in a patient, the device comprising:

a source of electrical energy;

an introducer configured for introduction through an incision in an outer skin surface of a neck of the patient;

one or more electrodes coupled to the source of electrical energy and configured for advancement through the introducer to a target site at or near a vagus nerve of the patient exterior to a carotid sheath of the vagus nerve; and

a control unit coupled to the source of electrical energy, wherein the control unit is configured to control the source of electrical energy to generate an electrical impulse and to transmit the electrical impulse through the incision in the outer skin surface of the neck of the patient and the one or more electrodes to the vagus nerve, the electrical impulse being sufficient to modulate the vagus nerve to treat the medical disorder, wherein the medical disorder is bronchoconstriction and the electrical impulse is sufficient to increase a forced expiratory volume in 1 second (FEV1) of the patient by a clinically significant amount in a period of time less than 6 hours.

12. The device of claim 11, wherein the electrical impulse has a frequency from 15 HZ to 50 Hz.

13. The device of claim 11, wherein the electrical impulse is insufficient to simulate efferent fibers of the vagus nerve.

14. The device of claim 11, wherein the electrical impulse is of an amplitude from 1 volt to 12 volts.

15. The device of claim 11, wherein the electrical impulse has a pulsed on-time from 50 microseconds to 500 microseconds.