Porous polymeric formulation prepared using monomer

• US 9,828,620 B2
• Filed: 06/28/2013
• Issued: 11/28/2017
• Est. Priority Date: 06/28/2013
• Status: Active Grant

• Current Assignee: Google LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Liu, Zenghe, Linhardt, Jeffrey George
• Primary Examiner(s): Kaur, Gurpreet
• Application Number:
  US13/930,858
• Publication Number:
  US 20150001073A1
• Time in Patent Office: 1,614 Days
• CPC Class Codes: C12Q 1/003 Functionalisation

Abstract

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks.

Claims

1. An analyte sensor comprising:

a crosslinked, hydrophilic copolymer in contact with a surface of an electrode; and

an analyte sensing component embedded within the crosslinked, hydrophilic copolymer,

wherein the crosslinked, hydrophilic copolymer consists of;

backbone chains comprising;

first methacrylate-derived units, each having a first hydrophilic side chain;

second methacrylate-derived units, each having a second hydrophilic side chain,

wherein the first hydrophilic side chain and the second hydrophilic side chains are the same or different;

third methacrylate-derived units; and

hydrophilic crosslinks between the third methacrylate-derived units in different backbone chains, wherein the hydrophilic crosslinks comprise poly(alkylene oxide).

2. The sensor according to claim 1, wherein the side chain of the first methacrylate-derived units comprise one or more hydroxy groups.

3. The sensor according to claim 1, wherein the first methacrylate-derived units have the structure of formula (Ia):

4. The sensor according to claim 1, wherein the first methacrylate-derived units have the structure:

5. The sensor according to claim 1, wherein the second methacrylate-derived units comprise one or more alkylene oxide units.

6. The sensor according to claim 1, wherein the second methacrylate-derived units have the structure of formula (II):

7. The sensor according to claim 1, wherein the second methacrylate-derived units have the structure of formula:

(II);

8. The sensor according to claim 1, wherein the hydrophilic crosslinks have the structure of formula (IIIa):

9. The sensor according to claim 1, wherein the hydrophilic crosslinks have the structure of formula (IIIa):

10. The sensor according to claim 1, wherein the analyte sensing component comprises glucose oxidase.

11. The sensor according to claim 1, wherein the crosslinked, hydrophilic copolymer has a thickness of about 20 μ

m.

12. The sensor according to claim 1, wherein

the first methacrylate-derived units are derived from 2-hydroxyethylmethacrylate;

the second methacrylate-derived units have the structure of formula (II);