Transcutaneous analyte sensor

• US 9,833,143 B2
• Filed: 06/05/2014
• Issued: 12/05/2017
• Est. Priority Date: 05/03/2004
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brister, Mark, Neale, Paul V., Simpson, Peter C., Brauker, James H., Thrower, James Patrick, Shults, Mark, Rhodes, Rathbun K., Goode, Jr., Paul V., Holmquist, Arnold L.
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US14/296,735
• Publication Number:
  US 20140288403A1
• Time in Patent Office: 1,279 Days
• Field of Search: 600309, 600345-365
• CPC Class Codes: A61B 2560/04 Constructional details of apparatus
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2562/247 Hygienic covers, i.e. for covering the sensor or apparatus during use
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: H04B 1/03 Constructional details, e.g. casings, housings

Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Claims

1. An analyte measuring system, comprising:

a mounting unit adapted for mounting on a skin of a host;

an electronics unit comprising contacts, wherein the electronics unit is detachably connectable to the mounting unit, wherein the electronics unit comprises electronic circuitry encapsulated within a substantially seamless body comprising the contacts exposed on an exterior of the substantially seamless body;

a sensor configured for measuring a level of an analyte, the sensor comprising an in vivo portion for insertion through the skin at an exit site of the host and an ex vivo portion connected to the contacts when the electronics unit is detachably connected to the mounting unit; and

an elastomeric sealing member configured to form a watertight seal around the exposed contacts on the exterior of the substantially seamless body and at electrical connection areas on the ex vivo portion of the sensor, wherein the elastomeric sealing member is connected to the mounting unit, wherein the elastomeric sealing member comprises at least one conductive elastomer contact disposed within the elastomeric sealing member.

2. The system of claim 1, wherein the substantially seamless body is encapsulated in a polymer material.

3. The system of claim 2, wherein the polymer material is water vapor permeable.

4. The system of claim 2, wherein the polymer material is epoxy.

5. The system of claim 1, wherein the electronic circuitry comprises an inductor for a voltage controlled oscillator.

6. The system of claim 1, wherein the electronic circuitry further comprises a microprocessor, RF circuitry, an antenna and a power source encapsulated within the substantially seamless body.

7. The system of claim 1, wherein at least a portion of the electronic circuitry comprises a conformal coating.

8. The system of claim 1, wherein the mounting unit comprises an opening configured to receive sensor electronics therein.

9. The system of claim 2, wherein the polymer material is at least one of epoxy, silicone or urethane.

10. The system of claim 1, wherein the substantially seamless body is monolithic.

11. The system of claim 1, wherein the substantially seamless body comprises secure and seamless encapsulation of the contacts in a polymer material and provides for mechanical alignment, security, and reduces or eliminates leakage of water therethrough.

12. The system of claim 1, wherein the substantially seamless body comprises a curvature.

13. The system of claim 12, wherein the curvature comprises rounded edges comprising a plurality of radii of curvature.

14. The system of claim 13, wherein the plurality of radii of curvature comprise radii of curvature of at least about 0.5 mm.

15. The system of claim 1, wherein the elastomeric sealing member forms an interference fit with the electronics unit.

16. The system of claim 1, further comprising a sealant configured to provide a moisture barrier between the sensor and the contacts.

17. The system of claim 1, wherein the sensor is configured to extend through the at least one conductive elastomer contact.

18. An analyte measuring system, comprising:

a mounting unit adapted for mounting on a skin of a host, wherein at least a portion of the mounting unit is formed of an elastomeric material;

an electronics unit comprising contacts, wherein the electronics unit is detachably connectable to the mounting unit, wherein the electronics unit comprises electronic circuitry encapsulated within a substantially seamless body comprising the contacts exposed on an exterior of the substantially seamless body;

a sensor configured for measuring a level of an analyte, the sensor comprising an in vivo portion for insertion through the skin at an exit site of the host and an ex vivo portion connected to the contacts when the electronics unit is detachably connected to the mounting unit; and

an elastomeric sealing member configured to form a watertight seal around the exposed contacts on the exterior of the substantially seamless body and at electrical connection areas on the ex vivo portion of the sensor, wherein the elastomeric sealing member is connected to the mounting unit, wherein the elastomeric sealing member comprises at least one conductive elastomer contact disposed within the elastomeric sealing member.

19. The system of claim 18, wherein the elastomeric material is silicone.