Transdermal analyte sensing device

• US 9,855,000 B2
• Filed: 05/18/2016
• Issued: 01/02/2018
• Est. Priority Date: 05/18/2015
• Status: Active Grant

• Current Assignee: Milo Sensors Inc.
• Original Assignee: Milo Sensors Inc.
• Inventors: Lansdorp, Bob, Strenk, Evan, Arroyo, Netz, Imberman, Daniel
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US15/158,258
• Publication Number:
  US 20160338627A1
• Time in Patent Office: 594 Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/681 Wristwatch-type devices

Abstract

There is disclosed a transdermal analyte sensor device. The device includes a sensor cartridge having a membrane permeable to a target analyte transdermally received from a subject, a reservoir containing a fluid to receive the target analyte through the membrane and an enzyme to react with the target analyte to form a byproduct, a working electrode to generate an electrical current based on a concentration of a byproduct, and a cartridge electrical contact to transmit the electrical current. The device also includes a device body having a device electrical contact to receive the electrical current from the cartridge electrical contact, a transmitter to transmit a signal based on the electrical current to a monitoring device, and a cartridge receptacle to receive the sensor cartridge and position the membrane to contact skin of the subject.

Claims

1. A transdermal analyte sensor device comprising:

a sensor cartridge comprising;

a membrane permeable to a target analyte transdermally received from a subject,

a reservoir containing a fluid to receive the target analyte through the membrane and an enzyme to react with the target analyte to form a byproduct,

a working electrode to generate an electrical current based on a concentration of a byproduct, and

a cartridge electrical contact disposed on a flange to transmit the electrical current from the working electrode; and

a device body comprising;

a device electrical contact to receive the electrical current from the cartridge electrical contact,

a transmitter to transmit a signal based on the electrical current to a monitoring device, and

a cartridge receptacle configured to slidably receive the sensor cartridge and position the membrane to contact skin of the subject, wherein when the sensor cartridge is slidably received in the cartridge receptacle, the flange is received in a recess of the cartridge receptacle such that the cartridge electrical contact is electrically coupled to the device electrical contact.

2. The transdermal analyte sensor device of claim 1, wherein the analyte is ethanol.

3. The transdermal analyte sensor device of claim 1, wherein the analyte is urea.

4. The transdermal analyte sensor device of claim 1, wherein the analyte is glucose.

5. The transdermal analyte sensor device of claim 1, wherein the enzyme comprises alcohol oxidase.

6. The transdermal analyte sensor device of claim 1, wherein the enzyme comprises horseradish peroxidase.

7. The transdermal analyte sensor device of claim 1, wherein the working electrode comprises glassy carbon.

8. The transdermal analyte sensor device of claim 7, wherein the working electrode is coated with Prussian Blue.

9. The transdermal analyte sensor device of claim 1, wherein the membrane comprises polyethylene.

10. The transdermal analyte sensor device of claim 1, wherein the membrane comprises nylon.

11. The transdermal analyte sensor device of claim 1, wherein the sensor cartridge further comprises a reservoir electrode to transmit the electrical current.

12. The transdermal analyte sensor device of claim 11, wherein the reservoir electrode comprises silver.

13. The transdermal analyte sensor device of claim 11, wherein the reservoir electrode comprises a silver-chloride coating.

14. The transdermal analyte sensor device of claim 1 further comprising a wristband to fasten the sensor device to the subject.

15. The transdermal analyte sensor device of claim 1, wherein a fluid seal between the membrane and the sensor cartridge maintains the fluid in the reservoir.

16. The transdermal analyte sensor device of claim 1, wherein the analyte passes through the membrane and into the reservoir as a fluid.

17. A method for transdermal analyte sensing using a device having an electrical contact, the method comprising:

transdermally receiving an analyte from a subject through a membrane of a sensor cartridge into a liquid, wherein the sensor cartridge comprises a flange and is configured to be slidably received in a cartridge receptacle of a device body having a device electrical contact to position the membrane to contact skin of a subject;

generating an electrical current based on a concentration of the analyte in the liquid; and

transmitting a signal based on the electrical current,

wherein when the sensor cartridge is slidably received in the cartridge receptacle, the flange is received in a recess of the cartridge receptacle such that the cartridge electrical contact is electrically coupled to the device electrical contact.

18. The method of claim 17, wherein the analyte is ethanol.

19. The method of claim 17, wherein the analyte is glucose.

20. The method of claim 17, wherein the analyte is urea.

21. A method for determining blood concentration of an analyte in a subject, the method comprising:

receiving a signal from a device, the signal based on a concentration of a liquid analyte transdermally received from the subject through a membrane of a sensor cartridge, wherein a cartridge receptacle comprises a flange and is configured to be slidably received in a cartridge receptacle of a device body having a device electrical contact to position the membrane to contact skin of the subject; and

wherein when the sensor cartridge is slidably received in the cartridge receptacle, the flange is received in a recess of the cartridge receptacle such that the cartridge electrical contact is electrically coupled to the device electrical contact, and

displaying a blood analyte concentration based on the signal.

22. The method of claim 21, wherein the analyte is ethanol.

23. The method of claim 21, wherein the analyte is glucose.

24. The method of claim 21, wherein the analyte is urea.

25. The method of claim 21 further comprising:

receiving subject information; and

displaying the blood analyte concentration further based on the subject information.

26. The method of claim 21 further comprising:

receiving alert criteria; and

sending an alert based on the alert criteria and the blood analyte concentration.