Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions

CAFC
  • US 9,855,221 B2
  • Filed: 02/21/2017
  • Issued: 01/02/2018
  • Est. Priority Date: 10/12/2001
  • Status: Active Grant
First Claim
Patent Images

1. A continuously cast film for delivery of an active in individual self-supporting oral unit doses, said individual self-supporting oral unit doses cut from said continuously cast film containing a desired amount of said active, said continuously cast film comprising:

  • an ingestible, water-soluble, polymer matrix;

    at least one anti-tacking agent selected from the group consisting of stearate;

    stearic acid;

    vegetable oil;

    wax;

    a blend of magnesium stearate and sodium lauryl sulfate;

    boric acid;

    surfactant;

    sodium benzoate;

    sodium acetate;

    sodium chloride;

    DL-Leucine;

    polyethylene glycol;

    sodium oleate;

    sodium lauryl sulfate;

    magnesium lauryl sulfate;

    talc;

    corn starch;

    amorphous silicon dioxide;

    silicon dioxide;

    metallic stearate;

    Vitamin E;

    Vitamin E TPGS;

    silica and combinations thereof; and

    a substantially uniform distribution of said active substantially locked-in within said polymer matrix, wherein said active is selected from the group consisting of cosmetic agents,pharmaceutical agents, vitamins, bioactive agents and combinations thereof wherein said active is substantially uniformly distributed in said continuously cast film, whereby said substantially uniform distribution is measured by substantially equally sized individual self supporting oral unit doses cut from said continuously cast film which do not vary by more than 10% of said desired amount of said active.

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