Protein material

• US 9,861,687 B2
• Filed: 08/23/2017
• Issued: 01/09/2018
• Est. Priority Date: 07/31/2012
• Status: Active Grant

• Current Assignee: Megmilk Snow Brand Company Limited
• Original Assignee: Megmilk Snow Brand Company Limited
• Inventors: Ohmachi, Aiko, Matsuyama, Hiroaki, Morita, Yoshikazu, Ishida, Yuko, Nara, Takayuki, Kato, Ken, Serizawa, Atsushi
• Primary Examiner(s): Underdahl, Thane
• Application Number:
  US15/684,175
• Publication Number:
  US 20170348399A1
• Time in Patent Office: 139 Days
• Field of Search: None
• CPC Class Codes: A23K 20/142 Amino acids; Derivatives thereof
• CPC Class Codes: A23K 20/147 Polymeric derivatives, e.g. peptides or proteins
• CPC Class Codes: A23K 20/189 Enzymes
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23L 2/66 Proteins
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/00 Function of food ingredients
• CPC Class Codes: A23V 2200/306 having an effect on bone mass, e.g. osteoporosis prevention
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/1891 Angiogenesic factors; Angiogenin
• CPC Class Codes: A61K 38/44 Oxidoreductases (1)
• CPC Class Codes: A61K 38/465 acting on ester bonds (3.1), e.g. lipases, ribonucleases
• CPC Class Codes: A61K 38/54 Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C12Y 111/01007 Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
• CPC Class Codes: C12Y 301/27 : Endoribonucleases producing 3'-phosphomonoesters (3.1.27)

Abstract

The invention relates to a protein material includes angiogenin and/or angiogenin hydrolysate in an amount of 2 to 15 mg/100 mg, and lactoperoxidase and/or lactoperoxidase hydrolysate, in the mass ratio to angiogenin and/or angiogenin hydrolysate of 0.3 to 20.

Claims

1. A protein material comprising angiogenin and/or angiogenin hydrolysate in an amount of 2 to 15 mg/100 mg and lactoperoxidase and/or lactoperoxidase hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.3:

1 to 20;

1.

2. A food, drink, or feed comprising the protein material according to claim 1.

3. A bone-strengthening agent comprising the protein material according to claim 1 as an active ingredient.

4. A method of strengthening bones comprising administering the protein material according to claim 1 in an amount of 5 mg/day or more.

5. A method of preparing the protein material according to claim 1, comprising following steps 1) to 3):

1) preparing angiogenin and/or angiogenin hydrolysate;

2) preparing lactoperoxidase and/or lactoperoxidase hydrolysate; and

3) mixing the lactoperoxidase and/or lactoperoxidase hydrolysate according to above

     2) and the angiogenin and/or angiogenin hydrolysate according to above

     1) in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.3;

1 to 20;

1.

6. A method of preparing the protein material according to claim 1, comprising a step of extracting a fraction containing angiogenin and/or angiogenin hydrolysate and lactoperoxidase and/or lactoperoxidase hydrolysate from milk and/or a material derived from milk in the mass ratio to the angiogenin and/or the angiogenin hydrolysate of 0.3:

1 to 20;

1.

7. The method according to claim 6, further comprising another step of enzymatically degrading the angiogenin and/or the lactoperoxidase contained in the fraction.