External drug pump

• US 9,861,759 B2
• Filed: 08/12/2013
• Issued: 01/09/2018
• Est. Priority Date: 10/02/2007
• Status: Active Grant

• Current Assignee: West Pharma. Services IL, Ltd. (West Pharmaceutical Services Incorporated)
• Original Assignee: Medimop Medical Projects Ltd. (West Pharmaceutical Services Incorporated)
• Inventors: Gross, Yossi, Cabiri, Oz
• Primary Examiner(s): Hayman, Imani
• Assistant Examiner(s): Engel, Matthew A
• Application Number:
  US13/964,651
• Publication Number:
  US 20130331791A1
• Time in Patent Office: 1,611 Days
• Field of Search: 604 9301
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/1426 with means for preventing access to the needle after use
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/14533 cam actuated
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: F16H 25/12 with reciprocation along the axis of rotation, e.g. gearings with helical grooves and automatic reversal or cams
• CPC Class Codes: Y10T 74/18576 including screw and nut

Abstract

Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described.

Claims

1. An activation mechanism for a drug delivery device wearable by a patient, the activation mechanism comprising:

a base having a patient contact surface;

a hollow sleeve disposed on the base, the hollow sleeve having first and second ends and extending along a longitudinal axis between the first and second ends, the hollow sleeve having a holding portion, the holding portion extending generally longitudinally from the first end of the sleeve, the holding portion having a retaining surface arranged opposite to the first end of the sleeve, the retaining surface facing the patient contact surface of the base and extending generally perpendicularly with respect to the longitudinal axis, the retaining surface being positioned between the first end of the sleeve and the patient contact surface of the base;

a longitudinally extending needle having a sharp end and an opposed end;

a needle holder coupled to the opposed end of the needle and being movable along the longitudinal axis with respect to the sleeve between a withdrawn position, wherein the sharp end of the needle is disposed within the base, and an injection position, wherein the sharp end of the needle extends beyond the patient contact surface of the base;

a spring coupled to the needle holder and biasing the needle holder to the withdrawn position;

a longitudinally extending cannula having a free end and being sized to coaxially receive the needle therein;

a cannula holder coupled to the cannula opposite the free end thereof and movable along the longitudinal axis between a retracted position, wherein the free end of the cannula is disposed within the base and at least a portion of the cannula holder is disposed between the first and second ends of the sleeve, and an extended position, wherein the free end of the cannula extends beyond the patient contact surface of the base, and

wherein the retaining surface of the holding portion abuts a generally radially extending ledge of the cannula holder when the needle holder is in the withdrawn position and the cannula holder is in the extended position to prevent relative movement of the cannula holder to the retracted position.

2. The activation mechanism of claim 1, wherein the spring surrounds at least a portion of the needle.

3. The activation mechanism of claim 1, wherein when the needle holder is in the withdrawn position, the sharp end of the needle is disposed within the cannula holder.

4. The activation mechanism of claim 1, wherein the needle holder includes a retention surface that is oriented generally parallel to the patient contact surface and is in contact with the spring.

5. The activation mechanism of claim 1, wherein a portion of the needle holder is disposed within the cannula holder when the needle holder is in the injection position and the cannula holder is in the extended position.

6. The activation mechanism of claim 1, wherein a portion of the needle holder is disposed within the cannula holder when the needle holder is in the withdrawn position and the cannula holder is in the retracted position.