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Morphinan compounds

  • US 9,868,976 B2
  • Filed: 03/11/2016
  • Issued: 01/16/2018
  • Est. Priority Date: 05/01/2007
  • Status: Active Grant
First Claim
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1. A method of evaluating the metabolic stability of a deuterated morphinan compound, comprising:

  • a. contacting a first amount of the deuterated morphinan compound with a metabolizing enzyme source for a period of time sufficient to allow the formation of a mixture comprising one or more metabolic products of the deuterated morphinan compound and a remaining amount of the deuterated morphinan compound;

    b. at the period of time, determining the remaining amount of the deuterated morphinan compound and the amount of at least one of the one or more metabolic products in the mixture; and

    c. comparing the remaining amount of the deuterated morphinan compound determined in step b. with the first amount of the deuterated morphinan compound and/or comparing the first amount of the deuterated morphinan compound with the amount of the at least one of the one or more metabolic products determined in step b. to determine the metabolic stability of the deuterated morphinan compound, wherein the metabolic stability is expressed as the % of the amount of the deuterated morphinan compound determined in step b. relative to the first amount and/or as the % of the at least one of the one or more metabolic products determined in step b. relative to the first amount of the deuterated morphinan compound, wherein the deuterated morphinan compound is a compound of Formula I

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