Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors

  • US 9,882,660 B2
  • Filed: 04/30/2014
  • Issued: 01/30/2018
  • Est. Priority Date: 10/26/2006
  • Status: Active Grant
First Claim
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1. A system for detecting signal attenuation comprising:

  • an analyte sensor for positioning under a skin surface in fluid contact with bodily fluid; and

    a data processing device comprising a memory, wherein the data processing device is operatively coupled to the analyte sensor, the data processing device configured to receive a first plurality of analyte sensor related signals from the analyte sensor within a first predetermined time period determined within the first 24 hours of analyte sensor positioning under the skin surface,wherein a computer program is stored on the memory such that, when executed, the computer program causes the data processing device;

    to determine a probability of signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals,to determine a sensitivity of the analyte sensor based on a second plurality of analyte sensor related signals from the analyte sensor and a reference analyte measurement, the reference analyte measurement comprising a finger stick measurement of a blood analyte level,to determine a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity determined prior to analyte sensor positioning, the nominal sensitivity comprising a sensitivity value of the analyte sensor at the time of manufacture, andto verify a presence of signal attenuation associated with a decline in analyte sensor sensitivity when the determined sensitivity ratio is less than a first predetermined signal attenuation threshold level.

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