Antagonist antibodies directed against calcitonin gene-related peptide

  • US 9,890,210 B2
  • Filed: 05/05/2017
  • Issued: 02/13/2018
  • Est. Priority Date: 11/14/2005
  • Status: Active Grant
First Claim
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1. A humanized monoclonal anti-Calcitonin Gene-Related Peptide (CGRP) antagonist antibody, comprising:

  • two human IgG heavy chains, each heavy chain comprising three complementarity determining regions (CDRs) and four framework regions, wherein portions of the two heavy chains together form an Fc region; and

    two light chains, each light chain comprising three CDRs and four framework regions;

    wherein the CDRs impart to the antibody specific binding to a CGRP consisting of amino acid residues 1 to 37 of SEQ ID NO;

    15 or SEQ ID NO;


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