NIRS device with optical wavelength and path length correction

• US 9,907,494 B2
• Filed: 04/18/2012
• Issued: 03/06/2018
• Est. Priority Date: 04/18/2012
• Status: Active Grant

• Current Assignee: Fortiori Design LLC
• Original Assignee: Hutchinson Technology Incorporated (TDK Corporation)
• Inventors: Scheele, Bryan J., Finstrom, Nicholas H., Schmitz, Roger W.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US13/449,889
• Publication Number:
  US 20130281803A1
• Time in Patent Office: 2,148 Days
• Field of Search: 600310, 600316, 600322, 600323, 600326, 600328, 600338, 600340, 600344, 600473, 600476, 356 41
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor

Abstract

A near infrared spectrometer and method for wavelength and path length correction are disclosed. The spectrometer includes a number of photodiodes that transmit broadband near infrared measurement light into the tissue and at least one broadband detector which measures the light signal transmitted through the tissue. A processor estimates chromophore concentrations through a comparison of measured light attenuation and modeled light attenuation. The light attenuation model utilizes a light path length distribution derived from a Monte Carlo model and accounts for the spectral shape of the light source as a function of temperature.

Claims

1. A near infrared spectrometer for sensing tissue oxygen measurements in body tissue, comprising:

a plurality of light sources configured to emit broadband, near infrared measurement light into body tissue;

a mixer positioned such that the plurality of light sources emit the measurement light directly into the mixer without passing through any light conditioning filter located between the mixer and the plurality of light sources;

at least one temperature sensor configured to sense at least one temperature of the plurality of light sources;

at least one broadband photodetector configured for sensing at least a portion of the measurement light reflected back from the body tissue; and

a processor configured to;

model light attenuations within the body tissue based at least in part on the at least one temperature;

predict at least one light attenuation value within the body tissue based on the modeled light attenuation; and

estimate at least one tissue chromophore concentration within the body tissue by comparing attenuations of the sensed measurement light reflected back from the body tissue to the at least one predicted light attenuation value,

wherein the at least one predicted light attenuation value comprises a plurality of predicted light attenuation values at a plurality of wavelength increments, wherein the processor is configured to sum the plurality of predicted light attenuation values, wherein the wavelength increments are smaller than a spectral width of each light source and a responsivity of the at least one broadband photodetector.

2. The spectrometer of claim 1 wherein the modeling of the light attenuations compensates for a spectral shape of each light source based at least in part on the at least one temperature.

3. The spectrometer of claim 2, wherein the spectral shape of each light source is pre-characterized at a plurality of temperatures.

4. The spectrometer of claim 3, wherein the spectral shape of each light source is interpolated or extrapolated from a plurality of pre-characterized temperatures.

5. The spectrometer of claim 1, wherein a path length distribution for each wavelength increment of the measurement light is predicted using a simulation model.

6. The spectrometer of claim 5, wherein the simulation model is a Monte Carlo model.

7. A near infrared spectrometer for sensing tissue oxygen measurements in body tissue, comprising:

a plurality of light sources configured to emit broadband, near infrared measurement light into body tissue;

a mixer positioned such that the plurality of light sources emit the measurement light into the mixer without passing through any light conditioning filter located between the mixer and the plurality of light sources;

at least one broadband photodetector configured for sensing at least a portion of the measurement light reflected back from the body tissue;

at least one temperature sensor configured for sensing at least one temperature of the light sources; and

a processor configured to;

model light attenuations within the body tissue based at least in part on the at least one temperature;

estimate at least one tissue chromophore concentration within the body tissue by comparing attenuations of the sensed measurement light reflected back from the body tissue to the modeled light attenuations; and

sum the modeled light attenuations in tissue at a plurality of wavelength increments, the wavelength increments being smaller than a spectral width of each light source and a responsivity of the at least one broadband photodetector.

8. A method for determining one or more tissue oxygen measurements in body tissue, the method comprising:

coupling a spectrometer to a tissue of interest, the spectrometer including;

a plurality of light sources configured to emit broadband, near infrared measurement light into the body tissue;

at least one temperature sensor configured to sense at least one temperature of the light sources;

a mixer positioned such that the plurality of light sources emit the measurement light into the mixer without passing through any light conditioning filter located between the mixer and the plurality of light sources;

a processor; and

at least one broadband photodetector configured for sensing at least a portion of the measurement light reflected back from the body tissue;

measuring the attenuation of the measurement light reflected back from the body tissue using the at least one broadband photodetector;

predicting light attenuation within the body tissue using the processor, the predicted light attenuation predicted based on the at least one temperature and a light attenuation model;

summing a plurality of predicted attenuations of light in tissue at a plurality of wavelength increments, the wavelength increments being smaller than a spectral width of each light source and a responsivity of the at least one broadband photodetector; and

estimating, using the processor, at least one tissue chromophore concentration within the body tissue by comparing the attenuation of the measurement light reflected back from the body tissue to the predicted light attenuation,

wherein the modeling of the light attenuation compensates for a spectral shape of each light source based at least in part on the at least one temperature.