Medical measuring device

• US 9,924,886 B2
• Filed: 08/09/2006
• Issued: 03/27/2018
• Est. Priority Date: 08/09/2005
• Status: Active Grant

• Current Assignee: Ingo Flore
• Original Assignee: Ingo Flore
• Inventors: Cho, Ok Kyung, Kim, Yoon Ok
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US11/990,316
• Publication Number:
  US 20080275317A1
• Time in Patent Office: 4,248 Days
• Field of Search: 600309-344
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/02433 for infrared radiation
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar

Abstract

The invention relates to a measuring device (1) for the non-invasive measurement of physiological parameters. The measuring device (1) is suited to detect and localize by way of self diagnosis diseases such as, for example, inflammations, tumors or arteriosclerosis. The invention proposes a measuring device (1) with at least one optical measuring unit (100) for the generation of oximetric and/or plethysmographic measuring signals, an evaluation unit (140) processing the measuring signals, and a unit (120, 130) for the acquisition of local tissue parameters such as fat content, water content and/or blood perfusion, with the evaluation unit (140) being designed such that at least one local metabolic parameter is determined, in particular the local oxygen consumption, from the signals furnished by the optical measuring unit and obtained from tissue parameters. Moreover, the measuring device (1) enables the non-invasive determination of the glucose concentration.

Claims

1. A device for determining a local glucose concentration, the device comprising:

at least one optical measuring unit, wherein said at least one optical measuring unit produces oximetric measurement signals and plethysmographic measurement signals,

an ECG unit, wherein said ECG unit detects an ECG signal by way of two or more ECG electrodes,

a bioelectric impedance measuring unit comprising electrodes wherein said bioelectric impedance measuring unit detects bioelectric impedance signals,

an evaluation unit, and

a heat measuring unit comprising at least one heat sensor, wherein the heat measuring unit determines local heat production, wherein local heat production is a difference arising between an arterial temperature measured by the at least one heat sensor and a temperature the skin surface would reach in case of a perfect thermal insulation,

wherein the ECG unit and the bioelectric impedance measuring unit have at least one common electrode,

wherein the ECG unit, the bioelectric impedance measuring unit, the at least one optical measuring unit, and the at least one heat sensor are arranged in a common measuring head,

wherein said evaluation unit is adapted to determine a local glucose concentration from a combination of;

the local heat production determined by the heat measuring unit,

a local oxygen consumption determined from the measurement signals produced by the at least one optical measuring unit and the bioelectric impedance signals detected by the bioelectric impedance measuring unit, and

a correction factor determined from the ECG signals detected by the ECG unit and the measurement signals produced by the at least one optical measuring unit.

2. The device according to claim 1, wherein the bioelectric impedance measuring unit is adapted to detect comprehensive body tissue parameters.

3. The device according to claim 1, wherein the at least one optical measuring unit includes an optical radiation source and a radiation sensor.

4. The device according to claim 1, further comprising an optical sensor for spatially resolved determination of the skin coloring.

5. The device according to claim 1, wherein the evaluation unit is further adapted to evaluate the variation in respect of time of a plethysmograpic signal detected by the at least one optical measuring unit, and

wherein the evaluation unit is further adapted to determine a pulse wave speed from the variation in respect of time of the ECG signal and from the variation in respect of time of the plethysmographic signal.

6. The device according to claim 5, wherein the evaluation unit is adapted to evaluate the variation in respect of time of the pulse wave speed and to ascertain the composition of food ingested by a user of the device based on the basis of the variation in respect of time of the pulse wave speed from the time of food ingestion.

7. The device according to claim 1, wherein said evaluation unit is adapted to determine a blood glucose level of the user of the device using parameters dependent on the local glucose concentration.

8. The device according to claim 1, further comprising a storage unit,

wherein the storage unit stores the parameters ascertained by the evaluation unit.

9. The device according to claim 1, further comprising a diagnostic unit,

wherein the diagnostic unit assesses the parameters ascertained by the evaluation unit and records changes in the parameters in dependence on at least one of the measurement location and the measurement time.

10. The device according to claim 9, wherein the diagnostic unit is adapted to determine the status of the cardiovascular system from the parameters ascertained by the evaluation unit.

11. The device according to claim 9, wherein the diagnostic unit is adapted to calculate a comprehensive body fitness index on the basis of the status of the cardiovascular system and comprehensive body-wide tissue parameters.

12. The device according to claim 1, wherein the optical measuring unit has

at least one radiation source for irradiation of the body tissue being examined and

at least one radiation sensor for at least one of detection of the radiation scattered by the body tissue and detection of the radiation transmitted by the body tissue.

13. The device according to claim 12, wherein at least two radiation sources are provided which irradiate different volume regions of the body tissue being examined.

14. The device according to claim 13, wherein the at least two radiation sources have different spatial radiation emission characteristics.

15. The device according to claim 13, wherein the evaluation unit is further adapted to determine at least one local metabolic parameter from at least one of the radiation of the two radiation sources scattered by the body tissue and the radiation of the two radiation sources transmitted by the body tissue.

16. The device according to claim 15, wherein the evaluation unit is further adapted to determine at least one of the local oxygen consumption and the blood glucose level on the basis of the intensities of the radiation of the two radiation source, which is scattered, transmitted, or scattered and transmitted by the body tissue.

17. The device according to claim 13, wherein the wavelength of the radiation emitted by each of the two radiation sources is in the range of between 600 and 700 nm.

18. The device according to claim 1, wherein the optical measuring unit has at least one radiation source for irradiation of the body tissue being examined, and at least two radiation sensors for at least one of Detection of the radiation scattered by the body tissue and the radiation transmitted by the body tissue, and

wherein the radiation sensors are arranged at different spacings relative to the radiation source.

19. The device according to claim 1, wherein a housing accommodates the evaluation unit, and

wherein the measuring head is arranged at the front end of the housing so that the entire device is adapted to be hand-guiuded.

20. The device according to claim 19, wherein the housing has at least one further ECG electrode at the outside.

21. The device according to claim 20, wherein the at least one further ECG electrode is also adapted for bioelectrical impedance measurement.

22. The device according to claim 1, further comprising a display unit for displaying at least one of the local oxygen concentration of the blood and the at least one local metabolic parameter.

23. The device according to claim 1, further comprising an interface for connecting the device to a computer or another device.

24. The device according to claim 1, wherein said device is of miniature design is intergrated into an object worn on the body of a user.

25. Device according to claim 1, wherein the device is configured so that a body surface touched by a sensorical surface of the measuring head is less than or equal to 2 cm².

26. Device according to claim 1, wherein the optical measuring unit generates radiation in at least one of the visible spectrum and the near infrared spectrum.

27. A method for determining a local glucose concentration comprising:

measuring oximetric measuring signals and plethysomographic measuring signals by at least one optical measuring unit,

measuring a bioelectrical impedance signal by a bioelectrical impedance measuring unit,

determining a local heat production signal by a spatially resolved heat measurement carried out by a heat measuring unit comprising at least one heat sensor, wherein the local heat production signal is a difference arising between an arterial temperature measured by the at least one heat sensor and a temperature the skin surface would reach in case of a perfect thermal insulation, and

the measurement signals of the at least one optical measuring unit, the bioelectrical impedance signal of the bioelectrical impedance measuring unit, and the local heat production signal of the heat measuring unit are processed by an evaluation unit,

wherein the bioelectric impedance measuring unit, the at least one optical measuring unit, and the at least one heat sensor are arranged in a common measuring head,

wherein a local oxygen consumption is determined by the evaluation unit from the measuring signals from the at least one optical measuring unit and the bioelectrical impedance signal from the bioelectrical impedance measuring unit, and

wherein the local glucose concentration is determined by the evaluation unit from the local oxygen consumption and from the local heat production signal.

28. The method according claim 27, further comprising:

detecting ECG signals by an ECG unit by way of two or more ECG electrodes;

wherein the local glucose concentration is also determined on the basis of the ECG signals.

29. The method according to claim 28, wherein further local tissue parameters are measured via the bioelectrical impedance measuring unit.

30. The method according to claim 28, wherein further local tissue parameters are optically detected.

31. The method according to claim 27, wherein a cardiovascular parameter is determined by the evaluation unit from the plethysmographic measurement signals and ECG signals detected by an ECG unit.

32. The method according to claim 31, further comprising detection of comprehensive body tissue parameters, wherein a comprehensive body fitness index is calculated based on the cardiovascular parameter and the comprehensive body tissue parameters.

33. The method according to claim 27, further comprising detection of comprehensive body tissue parameters.

34. The method according to claim 27, wherein different volume regions of the body tissue being examined are irradiated by the optical measuring unit, and wherein the at least one local metabolic parameter is determined from ECG signals detected by an ECG unit and from at least one of the radiation scattered by the body tissue and the radiation transmitted by the body tissue in the different volume regions.

35. The method according to claim 34, wherein the optical measuring unit includes at least two radiation sources with different spatial radiation emission characteristics, and wherein at least one of the local oxygen consumption and the blood glucose level is determined on the basis of the intensities of the radiation of the two radiation sources, which is scattered by the body tissue, is transmitted by the body tissue, or is scattered and transmitted by the body tissue.

36. The method according to claim 27,

wherein further local tissue parameters are collected/detected via the bioelectrical impedance measuring unit as well as the ECG unit.

37. The method according to claim 36, wherein the evaluation unit determined the blood glucose level from the local glucose concentration and from parameters dependent on the physiology of the user on whom the non-invasive measuring takes place.

38. The method according to claim 27, wherein the determination of the local glucose concentration is effected with incorporation of data concerning the composition of food ingested by a user on whom the non-invasive measuring takes place.