Device and method for determining analyte levels

• US 9,931,067 B2
• Filed: 09/13/2016
• Issued: 04/03/2018
• Est. Priority Date: 03/04/1997
• Status: Expired due to Term

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Shults, Mark C., Updike, Stuart J., Rhodes, Rathbun K., Gilligan, Barbara J., Tapsak, Mark A.
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US15/264,577
• Publication Number:
  US 20170020418A1
• Time in Patent Office: 567 Days
• CPC Class Codes: A61B 2562/17 Comprising radiolucent components
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Claims

1. An implantable sensor system for measuring glucose, the system comprising:

an optical absorbance sensor configured to measure glucose;

sensor electronics operably connected to the sensor; and

a membrane disposed on at least a portion of the sensor, wherein the membrane comprises an outermost domain, wherein the outermost domain is configured to interface with tissue or a biological fluid, wherein the outermost domain comprises a metal portion.

2. The system of claim 1, wherein the membrane comprises polyurethane.

3. The system of claim 2, wherein the polyurethane is polyurethaneurea.

4. The system of claim 1, wherein the membrane comprises an enzyme.

5. The system of claim 4, wherein the enzyme is glucose oxidase.

6. The system of claim 1, wherein the metal is platinum.

7. An implantable sensor system for measuring glucose, the system comprising:

an optical absorbance sensor configured to measure glucose;

sensor electronics operably connected to the sensor; and

a membrane disposed on at least a portion of the sensor, wherein the membrane comprises polyurethane, wherein the membrane comprises an outermost domain, wherein the outermost domain is configured to interface with tissue or a biological fluid, wherein the outermost domain comprises a metal portion, wherein the metal portion comprises platinum.

8. An implantable sensor system for measuring glucose, the system comprising:

an optical absorbance sensor configured to measure glucose;

sensor electronics operably connected to the sensor; and

a membrane disposed on at least a portion of the sensor, wherein the membrane comprises polyurethaneurea, wherein the membrane comprises an outermost domain, wherein the outermost domain is configured to interface with tissue or a biological fluid, wherein the outermost domain comprises a metal portion, wherein the metal portion comprises platinum.