Enzyme delivery systems and methods of preparation and use
First Claim
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1. A method of treating cystic fibrosis, comprising administering to an individual having cystic fibrosis a therapeutically effective amount of a pharmaceutical composition comprising a coated digestive enzyme preparation, wherein the coated digestive enzyme preparation comprises particles that comprise:
- (a) a core comprising digestive enzymes, wherein the digestive enzymes comprise a protease, an amylase and a lipase, and wherein the digestive enzymes are present in the particles in an amount of from 70-90% by weight; and
(b) a coating comprising an emulsifiable lipid, wherein the coating coats the core and the emulsifiable lipid emulsifies upon exposure to a solvent.
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Abstract
This invention relates to coated digestive enzyme preparations and enzyme delivery systems and pharmaceutical compositions comprising the preparations. This invention further relates to methods of preparation and use of the systems, pharmaceutical compositions and preparations to treat persons having ADD, ADHD, autism, cystic fibrosis and other behavioral and neurological disorders.
275 Citations
28 Claims
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1. A method of treating cystic fibrosis, comprising administering to an individual having cystic fibrosis a therapeutically effective amount of a pharmaceutical composition comprising a coated digestive enzyme preparation, wherein the coated digestive enzyme preparation comprises particles that comprise:
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(a) a core comprising digestive enzymes, wherein the digestive enzymes comprise a protease, an amylase and a lipase, and wherein the digestive enzymes are present in the particles in an amount of from 70-90% by weight; and (b) a coating comprising an emulsifiable lipid, wherein the coating coats the core and the emulsifiable lipid emulsifies upon exposure to a solvent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification