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Enzyme delivery systems and methods of preparation and use

  • US 9,931,302 B2
  • Filed: 02/03/2015
  • Issued: 04/03/2018
  • Est. Priority Date: 04/13/2009
  • Status: Active Grant
First Claim
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1. A method of treating cystic fibrosis, comprising administering to an individual having cystic fibrosis a therapeutically effective amount of a pharmaceutical composition comprising a coated digestive enzyme preparation, wherein the coated digestive enzyme preparation comprises particles that comprise:

  • (a) a core comprising digestive enzymes, wherein the digestive enzymes comprise a protease, an amylase and a lipase, and wherein the digestive enzymes are present in the particles in an amount of from 70-90% by weight; and

    (b) a coating comprising an emulsifiable lipid, wherein the coating coats the core and the emulsifiable lipid emulsifies upon exposure to a solvent.

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