Immunogenic composition
First Claim
1. An immunogenic composition comprising conjugates of a plurality of N. meningitidis capsular saccharides and carrier protein, wherein said conjugates comprise a first N. meningitidis capsular saccharide which is N. meningitidis serogroup A capsular saccharide (MenA) or N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a first carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 1:
- 2-1;
5, and a second different N. meningitidis capsular saccharide conjugated to a second carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 5;
1-1;
1.99, wherein the second different capsular saccharide is a N. meningitidis serogroup Y capsular saccharide (MenY), a N. meningitidis serogroup W capsular saccharide (MenW) or a N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a linker with 1-cyano-4-dimethylamino pyridinium tetrafluoroborate (CDAP) chemistry, wherein the first carrier protein is conjugated to the linker with carbodiimide chemistry, optionally using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC), and wherein the composition does not include an adjuvant.
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Accused Products
Abstract
The present application relates to an immunogenic composition comprising at least 2 conjugates of N. meningitidis capsular saccharide and protein carrier, wherein said conjugates comprise at least 2 different N. meningitidis capsular saccharides selected from the group consisting of MenA, MenC, MenY and MenW, wherein at least one capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 1:2-1:5, and wherein at least one different capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 5:1-1:1.99.
99 Citations
17 Claims
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1. An immunogenic composition comprising conjugates of a plurality of N. meningitidis capsular saccharides and carrier protein, wherein said conjugates comprise a first N. meningitidis capsular saccharide which is N. meningitidis serogroup A capsular saccharide (MenA) or N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a first carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 1:
- 2-1;
5, and a second different N. meningitidis capsular saccharide conjugated to a second carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 5;
1-1;
1.99, wherein the second different capsular saccharide is a N. meningitidis serogroup Y capsular saccharide (MenY), a N. meningitidis serogroup W capsular saccharide (MenW) or a N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a linker with 1-cyano-4-dimethylamino pyridinium tetrafluoroborate (CDAP) chemistry, wherein the first carrier protein is conjugated to the linker with carbodiimide chemistry, optionally using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC), and wherein the composition does not include an adjuvant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- 2-1;
Specification