Immunogenic composition

  • US 9,931,397 B2
  • Filed: 06/23/2006
  • Issued: 04/03/2018
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
Patent Images

1. An immunogenic composition comprising conjugates of a plurality of N. meningitidis capsular saccharides and carrier protein, wherein said conjugates comprise a first N. meningitidis capsular saccharide which is N. meningitidis serogroup A capsular saccharide (MenA) or N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a first carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 1:

  • 2-1;

    5, and a second different N. meningitidis capsular saccharide conjugated to a second carrier protein with a saccharide to carrier protein ratio (w/w) ranging from 5;

    1-1;

    1.99, wherein the second different capsular saccharide is a N. meningitidis serogroup Y capsular saccharide (MenY), a N. meningitidis serogroup W capsular saccharide (MenW) or a N. meningitidis serogroup C capsular saccharide (MenC), wherein the first N. meningitidis capsular saccharide is conjugated to a linker with 1-cyano-4-dimethylamino pyridinium tetrafluoroborate (CDAP) chemistry, wherein the first carrier protein is conjugated to the linker with carbodiimide chemistry, optionally using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC), and wherein the composition does not include an adjuvant.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×