Optimizing mifepristone levels for cushing's patients

  • US 9,943,526 B2
  • Filed: 04/20/2016
  • Issued: 04/17/2018
  • Est. Priority Date: 04/21/2015
  • Status: Active Grant
First Claim
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1. A method for treating a patient suffering from Cushing'"'"'s syndrome, the method comprising:

  • A) treating said patient with seven or more daily doses of mifepristone over a period of seven or more days, wherein each of said daily doses contains an initial amount of mifepristone;

    B) testing the plasma mifepristone levels of the patient;

    thenC) if the plasma mifepristone levels of the patient are greater than 1631 ng/mL, continuing to treat the patient with said daily doses of mifepristone;

    orD) if the plasma mifepristone levels of the patient are less than or equal to 1631 ng/mL, continuing to treat the patient with daily doses of mifepristone, wherein each daily dose contains an amount of mifepristone that is greater than said initial amount of mifepristone; and

    E) repeating step B) and then step C) or step D);

    therebyadjusting the daily dose of the patient to achieve mifepristone plasma levels greater than 1631 ng/mL, with the proviso that the patient is not already suffering from a condition indicated for treatment with mifepristone,whereby mifepristone treatment optimized to achieve mifepristone plasma levels greater than 1631 ng/mL is provided to the patient suffering from Cushing'"'"'s syndrome.

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