Biomarker monitoring device and method

• US 9,946,836 B2
• Filed: 01/31/2011
• Issued: 04/17/2018
• Est. Priority Date: 01/31/2011
• Status: Active Grant

• Current Assignee: Robert Bosch GmbH
• Original Assignee: Robert Bosch GmbH
• Inventors: Kavusi, Sam, Lang, Christoph
• Primary Examiner(s): Alkafawi, Eman
• Application Number:
  US13/017,391
• Publication Number:
  US 20120197534A1
• Time in Patent Office: 2,633 Days
• Field of Search: 702 19, 702 20
• CPC Class Codes: G16B 50/00 ICT programming tools or database systems specially adapted for bioinformatics
• CPC Class Codes: G16B 50/30 Data warehousing; Computing architectures
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

Claims

1. A biomarker monitoring system comprising:

a communications network;

a portable wellness device configured to form a communication link with the communications network, the portable wellness device including

a detector configured to detect at least one biomarker in a biologic sample,

a first memory,

a plurality of program instructions stored in the first memory, and

a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data over a period of time based upon detection of the at least one biomarker in the biologic sample; and

a remote user interface operably connected to the communications network and configured to render the wellness data, wherein the rendered wellness data depicts a variation associated with the at least one biomarker during the period of time along with one or more of a depiction of a variation of a personal factor which may influence the health of an immune system during the period of time and depiction of a variation of an environmental factor which may influence the health of the immune system during the period of time.

2. The system of claim 1, wherein the portable wellness device includes a portable user interface and the processing circuit is further configured to execute the program instructions to render the wellness data with the portable user interface.

3. The system of claim 2, wherein the wellness data comprises quantitative data.

4. The system of claim 1, further comprising a second memory remote from the first memory, the second memory operably connected to the communications network, wherein the remote user interface renders wellness data stored in the second memory.

5. The system of claim 1, wherein the at least one biomarker comprises:

at least one first biomarker associated with a T helper 1 (Th1) cell;

at least one second biomarker associated with a T helper 2 (Th2) cell; and

at least one third biomarker associated with a T regulatory cell.

6. The system of claim 5, wherein each of the at least one first biomarker and the at least one second biomarker comprises a cytokine, a chemokine, a metalloproteinase, a toxicity biomarker, or an antigen.

7. The system of claim 5, wherein the wellness data is associated with the relative amount of the T helper 1 (Th1) cell and the T helper 2 (Th2) cell in the biologic sample.

8. The system of claim 7, wherein the depicted variation associated with the at least one biomarker comprises a depiction of the relative amount of the T helper 1 (Th1) cell and the T helper 2 (Th2) cell during the period of time.

9. The system of claim 8, wherein the wellness data comprises both the depiction of the variation of the personal factor during the period of time and the depiction of the variation of the environmental factor during the period of time one.

10. The system of claim 9, wherein the personal factor comprises one or more of:

a sleep period;

a medication;

or

a consumption.

11. The system of claim 9, wherein the environmental factor comprises one or more of:

a location;

an environmental condition;

or

an activity.

12. A biomarker monitoring system comprising:

a communications network;

a wearable detector device operably connectable to the communications network and configured to detect at least one biomarker in a biologic sample;

a memory operably connected to the communications network;

a plurality of program instructions stored in the memory;

a processing circuit operably connected to the communications network and configured to execute the program instructions to generate wellness data indicative of the status of an immune system over a period of time based upon detection of the at least one biomarker in the biologic sample; and

a user interface operably connected to the processing circuit and configured to render the wellness data in the form of a variation associated with the at least one biomarker during the period of time along with one or more of a depiction of a variation of a personal factor during the period of time and depiction of a variation of an environmental factor during the period of time.

13. The system of claim 12, wherein the wearable detector device includes the processing circuit and the user interface.

14. The system of claim 12, wherein the at least one biomarker comprises:

at least one first biomarker associated with a T helper 1 (Th1) cell; and

at least one second biomarker associated with a T helper 2 (Th2) cell.

15. The system of claim 14, wherein each of the at least one first biomarker and the at least one second biomarker comprises a cytokine, a chemokine, a metalloproteinase, a toxicity biomarker, or an antigen.

16. The system of claim 15, wherein the wellness data is associated with the relative amount of the T helper 1 (Th1) cell and the T helper 2 (Th2) cell in the biologic sample.

17. The system of claim 12, wherein the processing circuit is further configured to execute the program instructions to:

generate a second data based upon either a personal factor or an environmental factor.

18. The system of claim 17, wherein the processing circuit is further configured to execute the program instructions to generate wellness data based upon one or more of the group consisting of:

a sleep period of an individual;

a medication taken by an individual; and

a consumption of a substance by an individual.

19. The system of claim 17, wherein the processing circuit is further configured to execute the program instructions to generate the second data based upon one or more of the group consisting of:

a location of an individual;

an environmental condition around an individual; and

an activity of an individual.

20. The system of claim 17, wherein the processing circuit is further configured to execute the program instructions to:

generate the second data based upon a personal factor and an environmental factor.