System for converting biologic particle density data into dynamic images

• US 9,953,453 B2
• Filed: 02/28/2014
• Issued: 04/24/2018
• Est. Priority Date: 11/14/2012
• Status: Active Grant

• Current Assignee: Lawrence A. Lynn
• Original Assignee: Lawrence A. Lynn
• Inventors: Lynn, Lawrence A., Hunt, Michael, Karasinir, Cihan, Lynn, Eric N., Podorozhansky, Andrey
• Primary Examiner(s): Chng, Joy
• Application Number:
  US14/193,757
• Publication Number:
  US 20140176538A1
• Time in Patent Office: 1,516 Days
• Field of Search: 705 2- 3
• CPC Class Codes: G06Q 10/06311 Scheduling, planning or task assignment for a person or group
• CPC Class Codes: G06T 13/60 of natural phenomena, e.g. rain, snow, water or plants
• CPC Class Codes: G06T 13/80 2D [Two Dimensional] animation, e.g. using sprites
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 30/40 for processing medical images, e.g. editing
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A system for converting biologic particle density data into a motion image of at least one clinical condition such as sepsis, wherein the system comprises a processor programmed to detect a plurality of perturbations of the biologic particle densities associated with the clinical condition, detect or determine features of the perturbations, and detect or determine patterns of the perturbations. The processor can also be programmed to generate an image of the clinical condition comprised of time image components comprising a two dimensional user-facing map, wherein time extends along an axis away from the user facing map such that the map may be scrolled forward or backward over time to view different two dimensional images of the clinical condition.

Claims

1. A patient monitoring system for visually depicting a status of a clinical condition of a patient comprising:

one or more processors;

a display device; and

memory storing instructions that, when executed by the one or more processors, cause the patient monitoring system to

receive a plurality of time series, each time series being biologic particle density of a biologic particle type associated with the patient;

generate a plurality of perturbations by identifying changes in the biologic particle density values of the plurality of time series;

determine, for each perturbation, a plurality of properties of the perturbation, wherein the properties include at least one of a slope, a magnitude, a percent change, a change duration, a minimum, a maximum, and a change relative to a normal range for one of the plurality of biologic particle densities;

assign a severity value to each determined property of each perturbation, wherein the severity values correspond to the severity of the determined property with respect to at least one clinical condition, and wherein the severity values form a set of predefined severity values;

generate a plurality of severity profiles over time for each clinical condition, each severity profile being generated by determining the number of the plurality of properties of the perturbations associated with the clinical condition that match each of the predefined severity values;

generate an image for each of the plurality of severity profiles, each image having one or more cells, wherein each cell is assigned a color associated with one of the predefined severity values, and wherein the number of cells of each color corresponds to the determined number of the plurality of properties of the perturbations associated with the clinical condition that match each of the predefined severity values;

display, on the display device, a two-dimensional map having a plurality of locations, each location corresponding to one of the clinical conditions, and

display, for each location on the map, a sequence of the generated images for the severity profile associated with the clinical condition corresponding to said location such that the sequence of generated images forms a dynamic image that visually depicts the status of the clinical condition.

2. The patient monitoring system of claim 1, wherein the clinical condition comprises sepsis.

3. The patient monitoring system of claim 1, wherein:

the instructions, when executed, cause the patient monitoring system to automatically order a test of a biologic particle density based on an analysis of the received biologic particle density data.

4. The patient monitoring system of claim 1, wherein:

the instructions, when executed, cause the patient monitoring system to generate a severity profile of the plurality of severity profiles by executing a script associated with a clinical sub-condition, the script configured to generate the severity profile by aggregating at least two severity profiles generated for at least two perturbations associated with the clinical sub-condition.

5. The patient monitoring system of claim 4, wherein:

executing the script for the clinical sub-condition comprises executing, for each of the at least two perturbations, a sub-script configured to generate one of the at least two severity profiles by generating a plurality of severity values, each severity value corresponding to one of a plurality of properties of the perturbation.

6. The patient monitoring system of claim 5, wherein:

executing the sub-script comprises determining an occurrence of the perturbation.

7. The patient monitoring system of claim 6, wherein:

the plurality of properties of the perturbation comprises at least one of a slope, a magnitude, a percent change, a change duration, a minimum, a maximum, and a change relative to a normal range for one of the plurality of different biologic particle densities.

8. The patient monitoring system of claim 1, wherein:

each severity profile of the plurality of severity profiles comprises a plurality of severity values; and

each severity value of the plurality of severity values maps to a color of a plurality of colors.

9. The patient monitoring system of claim 1, wherein:

the instructions, when executed, cause the patient monitoring system to generate a severity profile of the plurality of severity profiles by generating a first severity profile associated with a clinical sub-condition, generating a second severity profile associated with the clinical sub-condition, and aggregating the first severity profile and the second severity profile to obtain the severity profile.

10. The patient monitoring system of claim 1, wherein:

the instructions, when executed, cause the patient monitoring system to generate a severity profile of the plurality of severity profiles by generating a first severity profile associated with a first clinical sub-condition, generating a second severity profile associated with a second clinical sub-condition, and aggregating the first severity profile and the second severity profile to obtain the severity profile.

11. The patient monitoring system of claim 1, wherein:

the instructions, when executed, cause the patient monitoring system to generate a severity profile of the plurality of severity profiles by aggregating a plurality of first severity profiles associated with a clinical sub-condition, each first severity profile being generated by aggregating a plurality of second severity profiles generated for a perturbation associated with the clinical sub-condition, each second severity profile being generated by aggregating a plurality of third severity profiles generated for a property of a plurality of properties of the perturbation.

12. The patient monitoring system of claim 1, wherein:

the map further comprises a label positioned proximate to the location, the label indicating the clinical condition.

13. The patient monitoring system of claim 1, wherein:

the visual appearance comprises at least one of a size of the cell, a shape of the cell, or a color distribution of the cell.

14. The patient monitoring system of claim 1, wherein:

the map further comprises a plurality of map regions, each map region of the plurality of map regions corresponding to a type of clinical subsystem of a plurality of types of clinical subsystems.

15. The patient monitoring system of claim 1, wherein:

the instructions, when executed, further cause the patient monitoring system to present, at the display device, a visual indication identifying a treatment of the patient and identifying a relationship of the treatment to one of the image components of the plurality of image components.

16. The patient monitoring system of claim 1, wherein generating the image for each of the plurality of severity profiles further comprises arranging the one or more cells in a spiral from a central position, wherein the cell in the central position corresponds to a highest severity value, and additional cells spiral outward from the central position in descending order of severity value.

17. A patient monitoring system for visually depicting a status of a clinical condition of a patient comprising:

one or more processors;

a display device; and

memory storing instructions that, when executed by the one or more processors, cause the patient monitoring system to

receive a plurality of time series, each time series being biologic particle density of a biologic particle type associated with the patient;

generate a plurality of perturbations by identifying changes in the biologic particle density values of the plurality of time series;

determine, for each perturbation, a plurality of properties of the perturbation, wherein the properties include at least one of a slope, a magnitude, a percent change, a change duration, a minimum, a maximum, and a change relative to a normal range for one of the plurality of biologic particle densities;

assign a severity value to each determined property of each perturbation, wherein the severity values correspond to the severity of the determined property with respect to at least one clinical condition;

generate a plurality of severity profiles over time for each clinical condition, each severity profile being generated by determining the number of the plurality of properties of the perturbations associated with the clinical condition having a given severity value;

generate an image for each of the plurality of severity profiles, each image having one or more cells, wherein each cell is assigned a color associated with one of the severity values, and wherein the number of cells of each color corresponds to the determined number of the plurality of properties of the perturbations associated with the clinical condition that have each of the given severity values;

display, on the display device, a two-dimensional map having a horizontal time axis and one or more columns extending across the horizontal time axis, wherein each column corresponds to a given time period, and

display, across the one or more columns, a sequence of the generated images for the severity profiles associated with the clinical conditions corresponding to the time period of each column such that the sequence of generated images visually depict the status of the clinical condition over time.

18. The patient monitoring system of claim 17, wherein the clinical condition is sepsis.

19. The patient monitoring system of claim 17, wherein:

the map further comprises a plurality of rows, each row of the plurality of rows corresponding to a type of clinical subsystem of a plurality of types of clinical subsystems.

20. The patient monitoring system of claim 17, wherein:

the instructions, when executed, further cause the patient monitoring system to present, at the display device, a visual indication identifying a treatment of the patient and identifying a relationship of the treatment to one of the image components of the plurality of image components.

21. A patient monitoring system for visually depicting a status of a clinical condition of a patient comprising:

one or more processors;

a display device; and

memory storing instructions that, when executed by the one or more processors, cause the patient monitoring system to

receive a plurality of time series, each time series being biologic particle density of a biologic particle type associated with the patient;

generate a plurality of perturbations by identifying changes in the biologic particle density values of the plurality of time series;

determine, for each perturbation, a plurality of properties of the perturbation, wherein the properties include at least one of a slope, a magnitude, a percent change, a change duration, a minimum, a maximum, and a change relative to a normal range for one of the plurality of biologic particle densities;

assign a severity value to each determined property of each perturbation, wherein the severity values correspond to the severity of the determined property with respect to at least one clinical condition;

generate a plurality of severity profiles over time for each clinical condition, each severity profile being generated by determining the number of the plurality of properties of the perturbations associated with the clinical condition having a given severity value;

generate an image for each of the plurality of severity profiles, each image having one or more cells, wherein each cell is assigned a color associated with one of the severity values, and wherein the number of cells of each color corresponds to the determined number of the plurality of properties of the perturbations associated with the clinical condition that have each of the severity values;

display, on the display device, a two-dimensional map having a plurality of locations, each location corresponding to one of the clinical conditions;

display, for each location on the map, a sequence of the generated images for the severity profile associated with the clinical condition corresponding to said location such that the sequence of generated images forms a dynamic image that visually depicts the status of the clinical condition; and

display, on the display device, a visual indication identifying a treatment of the patient and identifying a relationship of the treatment to one of the generated images.

22. The patient monitoring system of claim 21, wherein the clinical condition is sepsis.