Transmitted light detection type measurement apparatus for skin autofluorescence

• US 9,955,871 B2
• Filed: 03/18/2013
• Issued: 05/01/2018
• Est. Priority Date: 03/21/2012
• Status: Active Grant

• Current Assignee: Korea Electrotechnology Research Institute
• Original Assignee: Korea Electrotechnology Research Institute
• Inventors: Kang, Uk, Papayan, Garry V, Shin, Il Hyung, Lee, Dae Sic, Bae, Soo Jin, Kim, Guang Hoon
• Primary Examiner(s): KISH, JAMES M
• Application Number:
  US13/845,974
• Publication Number:
  US 20130281865A1
• Time in Patent Office: 1,870 Days
• Field of Search: None
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

The present invention provides a transmitted light detection type measurement apparatus for skin fluorescence, which is configured to perform light irradiation and light detection on a reference sample and a measurement target. The apparatus includes a first light source, a second light source, a first optical detector and a second optical detector, a light source switching controller, and an operator.

Claims

1. A transmitted light type measurement apparatus for measuring skin fluorescence, which is configured to perform light irradiation and light detection on a measurement target, the apparatus comprising:

a first light source configured to irradiate excitation light having a first wavelength on the measurement target so that the skin fluorescence is generated from the measurement target by the excitation light;

a second light source configured to irradiate light having a second wavelength which is different from the first wavelength on the measurement target;

a first optical detector disposed to detect transmitted light through the measurement target by the excitation light from the first light source;

a second optical detector disposed to detect the skin fluorescence generated from the measurement target by the excitation light from the first light source and transmitted light passing through the measurement target by light from the second light source;

a light source switching controller configured to control turning on and off of the first light source and the second light source;

an optical detector switching controller configured to control turning on and off of the first optical detector and the second optical detector; and

an operation part configured to calculate a skin fluorescence signal by correcting a signal based on the skin fluorescence and the transmitted light detected by the first optical detector and the second optical detector,

wherein the light source switching controller controls the first light source and the second light source such that the first light source is turned on when the second light source is turned off under a first condition and the first light source is turned off when the second light source is turned on under a second condition,

wherein the first optical detector is turned on only under the first condition and the second optical detector is turned on under the first condition and the second condition.

2. The transmitted light detection type measurement apparatus of claim 1, further comprising:

a pair of optical transmitters configured to transmit the excitation light irradiated from the first light source and the light from the second light source to the measurement target.

3. The transmitted light detection type measurement apparatus of claim 2, wherein the pair of optical transmitters comprise a first optical prism connected to the first light source and the second light source and a second optical prism connected to the first optical detector and the second optical detector.

4. The transmitted light detection type measurement apparatus of claim 3, wherein the first optical prism and the second optical prism are triangular prisms having a triangular section.

5. The transmitted light detection type measurement apparatus of claim 4, wherein the first optical prism has a first surface mounted with the first light source and the second light source.

6. The transmitted light detection type measurement apparatus of claim 4, wherein the second optical prism has a first surface mounted with the first optical detector and the second optical detector.

7. The transmitted light detection type measurement apparatus of claim 2, wherein the pair of optical transmitters comprise a first optical pipe connected to the first light source and the second light source and a second optical pipe connected to the first optical detector and the second optical detector.

8. The transmitted light detection type measurement apparatus of claim 7, wherein the first optical pipe has a first surface mounted with the first light source and the second light source, a second surface extending from the first surface to the measurement target, and a third surface contacted to the measurement target such that light is incident to the measurement target.

9. The transmitted light detection type measurement apparatus of claim 8, wherein the second surface of the first optical pipe is tapered such that a cross-sectional area thereof is reduced from the first surface to the third surface.

10. The transmitted light detection type measurement apparatus of claim 7, wherein the second optical pipe has a first surface mounted with the first optical detector and the second optical detector, a second surface extending from the first surface to the measurement target, and a third surface contacted to the measurement target such that light is incident to the measurement target.

11. The transmitted light detection type measurement apparatus of claim 10, wherein the second surface of the second optical pipe is tapered such that a cross-sectional area thereof is reduced from the first surface to the third surface.

12. The transmitted light detection type measurement apparatus of claim 7, further comprising a dichroic prism disposed at a side of the second optical pipe for dividing detected light into two wavelength bands.

13. The transmitted light detection type measurement apparatus of claim 12, where the first optical detector is disposed to detect reflected light from the dichroic prism, and the second optical detector is disposed to detect transmitted light from the dichroic prism.

14. The transmitted light detection type measurement apparatus of claim 1, wherein the first wavelength ranges from 350 nm to 390 nm.

15. The transmitted light detection type measurement apparatus of claim 1, wherein the second wavelength ranges from 420 nm to 460 nm.

16. The transmitted light detection type measurement apparatus of claim 1, wherein the switching controller is further configured to control each of the first light source and the second light source to be turned off before turning on each of the light sources.

17. The transmitted light detection type measurement apparatus of claim 1, wherein the switching controller is further configured to control the first light source and the second light source to repeat turning on and off at a period of 10 Hz to 100 Hz.

18. The transmitted light detection type measurement apparatus of claim 1, comprising:

an optical sensor comprising the first light source, the second light source, the first optical detector, and the second optical detector; and

a main body electrically connected to the optical sensor and comprising the operation part, wherein the optical sensor is detachable from the main body.

19. The transmitted light detection type measurement apparatus of claim 18, wherein the optical sensor comprises a memory for storing detected data.

20. The transmitted light detection type measurement apparatus of claim 1, comprising:

an optical sensor comprising the first light source, the second light source, the first optical detector, and the second optical detector; and

a main body electrically connected to the optical sensor and comprising the operation part wherein the optical sensor is detachable from the main body;

wherein the optical sensor comprises a first fixing part connected to the first light source and the second light source and a second fixing part connected to the first optical detector and the second optical detector, and the first and second fixing parts face each other to form an insertion space therebetween.

21. The transmitted light detection type measurement apparatus of claim 20, wherein the first light source and the second light source are disposed at a distal end of the first fixing part to directly irradiate light on the measurement target, and the first optical detector and the second optical detector are disposed at a distal end of the second fixing part to directly detect the transmitted light and the skin fluorescence.

22. The transmitted light detection type measurement apparatus of claim 21, wherein the first optical detector and the second optical detector are configured to form two sectors, and comprise band-pass filters at the front of the two sectors to divide light into a first wavelength (λ

1) and a second wavelength (λ

2), respectively.

23. The transmitted light detection type measurement apparatus of claim 21, wherein the first fixing part and the second fixing part are a clip to fix the measurement target while compressing the measurement target.

24. The transmitted light detection type measurement apparatus of claim 1, comprising:

an optical sensor comprising the first light source, the second light source, the first optical detector, and the second optical detector; and

a main body electrically connected to the optical sensor and comprising the operation part, wherein the optical sensor is detachable from the main body;

wherein the optical sensor comprises a common light source light guide for transmitting light irradiated from the first light source and the second light source in a shared manner.

25. The transmitted light detection type measurement apparatus of claim 24, wherein the optical sensor comprises a common detection light guide for transmitting the transmitted light and the skin fluorescence to the first optical detector and the second optical detector in a shared manner.

26. The transmitted light detection type measurement apparatus of claim 24, wherein the optical sensor comprises a first dichroic mirror on an optical path to transmit light irradiated from the first light source and the second light source to the common light source light guide.

27. The transmitted light detection type measurement apparatus of claim 26, wherein the optical sensor comprises a second dichroic mirror on an optical path to divide light from the common detection light guide and transmit the divided light to the first optical detector and the second optical detector.

28. The transmitted light detection type measurement apparatus of claim 27, further comprising a first detection filter between the second dichroic mirror and the first optical detector and a second detection filter between the second dichroic mirror and the second optical detector, wherein the first detection filter passes light of a first wavelength and inhibits light of a second wavelength, and the second detection filter inhibits light of the first wavelength and passes light of the second wavelength.

29. The transmitted light detection type measurement apparatus of claim 27, further comprising objective lenses between the first and second optical detectors and the second dichroic mirror to concentrate light passing the second dichroic mirror on the first optical detector and the second optical detector, respectively.

30. The transmitted light detection type measurement apparatus of claim 26, further comprising objective lenses between the first and second light sources and the first dichroic mirror to condense light irradiated from the first and second light sources, respectively.

31. The transmitted light detection type measurement apparatus of claim 1, comprising:

an optical sensor comprising the first light source, the second light source, the first optical detector, and the second optical detector;

a main body electrically connected to the optical sensor and comprising the operation part, wherein the optical sensor is detachable from the main body; and

a first light source light guide for transmitting light irradiated from the first light source and a second light source light guide for transmitting light irradiated from the second light source.

32. The transmitted light detection type measurement apparatus of claim 31, wherein the optical sensor comprises a first detection light guide for transmitting the transmitted light of the first light source to the first optical detector and a second detection light guide for transmitting the transmitted light of the second light source or the skin fluorescence to the second optical detector.

33. The transmitted light detection type measurement apparatus of claim 32, further comprising a first detection filter between the first light source light guide and the first optical detector to pass light of a first wavelength and inhibit light of a second wavelength, and a second detection filter between the second light source light guide and the second optical detector to inhibit light of the first wavelength and pass light of the second wavelength.

34. The transmitted light detection type measurement apparatus of claim 1, wherein the main body further comprises a display part, and the display part outputs the corrected skin fluorescence signals calculated in the operation part.