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Integrated sensor arrays for biological and chemical analysis

  • US 9,964,515 B2
  • Filed: 09/23/2015
  • Issued: 05/08/2018
  • Est. Priority Date: 10/22/2008
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • a chemical field effect transistor array in a circuit-supporting substrate, such transistor array having disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid, wherein such transistor array has a pitch of 10 μ

    m or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region, the at least one chemical field effect transistor generating the at least one output signal at a circuit node at a first time interval, a first switch between the chemical field effect transistor and the circuit node to couple a terminal of the chemical field effect transistor to the circuit node in response to a select signal;

    a reference circuit including a second switch directly connected to the circuit node for coupling a reference signal to the circuit node in response to a timing signal during a second time interval; and

    a sampling circuit producing an output signal as a function of a first sample obtained during the first time interval and a second sample obtained during the second time interval.

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