Plant extract composition for reducing localized fat and promoting weight loss as well as application thereof

• US 9,987,325 B2
• Filed: 08/28/2015
• Issued: 06/05/2018
• Est. Priority Date: 08/28/2014
• Status: Active Grant

• Current Assignee: Caliway Biopharmaceuticals Co., Ltd.
• Original Assignee: Caliway Biopharmaceuticals Co., Ltd.
• Inventors: Ling, Yu-Fang
• Primary Examiner(s): Mi, Qiuwen
• Application Number:
  US14/914,971
• Publication Number:
  US 20170157193A1
• Time in Patent Office: 1,012 Days
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 36/9066 Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61Q 19/06 for countering cellulitis

Abstract

Provided is a composition and a pharmaceutical composition for reducing localized fat or promoting weight loss, wherein the composition comprises a plant extract composition comprising resveratrol and turmeric extract and a weight ratio of resveratrol and turmeric extract ranges from 1:30 to 10:1. The composition and the pharmaceutical composition are primarily administered through localized injection to inhibit the growth of fat cells and promote fat cells apoptosis to reduce adipocytes, decrease localized fat deposition, and promote weight loss, without causing inflammation or necrosis on peripheral cells or tissues to avoid severe pain, so as to avoid inflammation, damage, and pain caused by surgical liposuction or non-surgical lipolysis products such as phosphatidylcholine and sodium deoxycholate.

Claims

1. A method for reducing localized fat at a local site of a subject, comprising a step of administering at the local site of the subject a therapeutically effective amount of a pharmaceutical composition comprising resveratrol and curcumin, wherein a weight ratio of resveratrol and curcumin ranges from 1:

30 to 9;

1.

2. The method as claimed in claim 1, wherein the subject is animal or human.

3. The method as claimed in claim 1, wherein the local site comprises face, jaw, arm, waist, abdomen or thighs.

4. The method as claimed in claim 1, wherein the step of administering comprises injection.

5. The method as claimed in claim 1, wherein the therapeutically effective amount of the pharmaceutical composition is from 0.4 mg/kg BW to 100 mg/kg BW.

6. The method as claimed in claim 5, wherein the therapeutically effective amount of the pharmaceutical composition is from 1 mg/kg BW to 60 mg/kg BW.

7. The method as claimed in claim 1, wherein said pharmaceutical composition has a weight ratio of resveratrol and curcumin in 1:

19 to 9;

1.

8. The method as claimed in claim 4, wherein the injection comprises subcutaneous fat injection, subcutaneous injection, or intravenous injection.

9. The method as claimed in claim 7, wherein the local site comprises face, jaw, arm, waist, abdomen or thighs.

10. The method as claimed in claim 7, wherein the step of administering comprises localized injection, subcutaneous implantation, implantable injection pump or transdermal administration.

11. The method as claimed in claim 10, wherein the localized injection comprises subcutaneous fat injection, or subcutaneous injection.

12. The method as claimed in claim 10, wherein the therapeutically effective amount of the pharmaceutical composition is from 0.4 mg/kg BW to 100 mg/kg BW.

13. The method as claimed in claim 12, wherein the therapeutically effective amount of the pharmaceutical composition is from 1 mg/kg BW to 60 mg/kg BW.

14. The method as claimed in claim 1, wherein the step of administering comprises subcutaneous implantation, implantable injection pump, or transdermal administration.

15. A method for weight loss of a subject, comprising a step of administering at a site of the subject a therapeutically effective amount of a pharmaceutical composition comprising resveratrol and curcumin, wherein a weight ratio of resveratrol and curcumin ranges from 1:

30 to 9;

1.

16. The method as claimed in claim 15, wherein the subject is animal or human.

17. The method as claimed in claim 15, wherein the step of administering comprises subcutaneous implantation, or implantable injection pump.

18. The method as claimed in claim 15, wherein the step of administering comprises localized injection.

19. The method as claimed in claim 15, wherein the therapeutically effective amount of the pharmaceutical composition is from 0.4 mg/kg BW to 100 mg/kg BW.

20. The method as claimed in claim 15, wherein the therapeutically effective amount of the pharmaceutical composition is from 1 mg/kg BW to 60 mg/kg BW.

21. The method as claimed in claim 15, wherein said pharmaceutical composition has a weight ratio of resveratrol and curcumin in 1:

19 to 9;

1.

22. The method as claimed in claim 18, wherein the localized injection comprises subcutaneous fat injection or subcutaneous injection.

23. The method as claimed in claim 21, wherein the step of administering comprises injection, subcutaneous implantation, or implantable injection pump.

24. The method as claimed in claim 23, wherein the injection comprises subcutaneous fat injection, subcutaneous injection or intravenous injection.

25. The method as claimed in claim 21, wherein the therapeutically effective amount of the pharmaceutical composition is from 0.4 mg/kg BW to 100 mg/kg BW.

26. The method as claimed in claim 21, wherein the therapeutically effective amount of the pharmaceutical composition is from 1 mg/kg BW to 60 mg/kg BW.